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BDBM24758 2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-6-methyl-3,4-dihydropyrimidin-4-one::pyrimidone, 35

SMILES: COc1cc2nccc(Oc3ccc(cc3F)-c3c(C)nc(Cc4ccccc4)[nH]c3=O)c2cc1OC

InChI Key: InChIKey=LNXBIINVDNXZNZ-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24758   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24758
PNG
(2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-...)
Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3c(C)nc(Cc4ccccc4)[nH]c3=O)c2cc1OC
Show InChI InChI=1S/C29H24FN3O4/c1-17-28(29(34)33-27(32-17)13-18-7-5-4-6-8-18)19-9-10-24(21(30)14-19)37-23-11-12-31-22-16-26(36-3)25(35-2)15-20(22)23/h4-12,14-16H,13H2,1-3H3,(H,32,33,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
489 -8.52n/an/an/an/an/a7.522



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 5766-79 (2008)


Article DOI: 10.1021/jm8006189
BindingDB Entry DOI: 10.7270/Q23X84XN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24758
PNG
(2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-...)
Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3c(C)nc(Cc4ccccc4)[nH]c3=O)c2cc1OC
Show InChI InChI=1S/C29H24FN3O4/c1-17-28(29(34)33-27(32-17)13-18-7-5-4-6-8-18)19-9-10-24(21(30)14-19)37-23-11-12-31-22-16-26(36-3)25(35-2)15-20(22)23/h4-12,14-16H,13H2,1-3H3,(H,32,33,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 489n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair