BDBM24761 N-[(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)(phenyl)methyl]propanamide::pyrimidone, 39

SMILES: CCC(=O)NC(c1ccccc1)c1ncc(-c2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)c2)c(=O)n1C

InChI Key: InChIKey=GXVVHBLXRQHBSX-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24761   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24761 (N-[(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluor...) Show SMILES CCC(=O)NC(c1ccccc1)c1ncc(-c2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)c2)c(=O)n1C Show InChI InChI=1S/C32H29FN4O5/c1-5-29(38)36-30(19-9-7-6-8-10-19)31-35-18-22(32(39)37(31)2)20-11-12-26(23(33)15-20)42-25-13-14-34-24-17-28(41-4)27(40-3)16-21(24)25/h6-18,30H,5H2,1-4H3,(H,36,38)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	71	-9.65	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24761 (N-[(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluor...) Show SMILES CCC(=O)NC(c1ccccc1)c1ncc(-c2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)c2)c(=O)n1C Show InChI InChI=1S/C32H29FN4O5/c1-5-29(38)36-30(19-9-7-6-8-10-19)31-35-18-22(32(39)37(31)2)20-11-12-26(23(33)15-20)42-25-13-14-34-24-17-28(41-4)27(40-3)16-21(24)25/h6-18,30H,5H2,1-4H3,(H,36,38)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human c-MET				Eur J Med Chem 46: 3675-80 (2011) Article DOI: 10.1016/j.ejmech.2011.05.031 BindingDB Entry DOI: 10.7270/Q2891676
					More data for this Ligand-Target Pair