null

SMILES: COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(C(NC(=O)N(C)C)c4ccccc4)n(C)c3=O)c2cc1OC

InChI Key: InChIKey=TWIHIHMDOCRFES-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24763   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24763 (1-[(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluor...) Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(C(NC(=O)N(C)C)c4ccccc4)n(C)c3=O)c2cc1OC Show InChI InChI=1S/C32H30FN5O5/c1-37(2)32(40)36-29(19-9-7-6-8-10-19)30-35-18-22(31(39)38(30)3)20-11-12-26(23(33)15-20)43-25-13-14-34-24-17-28(42-5)27(41-4)16-21(24)25/h6-18,29H,1-5H3,(H,36,40)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	368	-8.68	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM24763 (1-[(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluor...) Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(C(NC(=O)N(C)C)c4ccccc4)n(C)c3=O)c2cc1OC Show InChI InChI=1S/C32H30FN5O5/c1-37(2)32(40)36-29(19-9-7-6-8-10-19)30-35-18-22(31(39)38(30)3)20-11-12-26(23(33)15-20)43-25-13-14-34-24-17-28(42-5)27(41-4)16-21(24)25/h6-18,29H,1-5H3,(H,36,40)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	368	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human c-MET				Eur J Med Chem 46: 3675-80 (2011) Article DOI: 10.1016/j.ejmech.2011.05.031 BindingDB Entry DOI: 10.7270/Q2891676
					More data for this Ligand-Target Pair