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BDBM24763 1-[(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)(phenyl)methyl]-3,3-dimethylurea::pyrimidone, 41

SMILES: COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(C(NC(=O)N(C)C)c4ccccc4)n(C)c3=O)c2cc1OC

InChI Key: InChIKey=TWIHIHMDOCRFES-UHFFFAOYSA-N

Data: 1 KI  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24763   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24763
PNG
(1-[(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluor...)
Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(C(NC(=O)N(C)C)c4ccccc4)n(C)c3=O)c2cc1OC
Show InChI InChI=1S/C32H30FN5O5/c1-37(2)32(40)36-29(19-9-7-6-8-10-19)30-35-18-22(31(39)38(30)3)20-11-12-26(23(33)15-20)43-25-13-14-34-24-17-28(42-5)27(41-4)16-21(24)25/h6-18,29H,1-5H3,(H,36,40)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
368 -8.68n/an/an/an/an/a7.522



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 5766-79 (2008)


Article DOI: 10.1021/jm8006189
BindingDB Entry DOI: 10.7270/Q23X84XN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24763
PNG
(1-[(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluor...)
Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(C(NC(=O)N(C)C)c4ccccc4)n(C)c3=O)c2cc1OC
Show InChI InChI=1S/C32H30FN5O5/c1-37(2)32(40)36-29(19-9-7-6-8-10-19)30-35-18-22(31(39)38(30)3)20-11-12-26(23(33)15-20)43-25-13-14-34-24-17-28(42-5)27(41-4)16-21(24)25/h6-18,29H,1-5H3,(H,36,40)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 368n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair