BDBM24766 5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-3-methyl-2-(phenylamino)-3,4-dihydropyrimidin-4-one::pyrimidone, 48
SMILES: COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(Nc4ccccc4)n(C)c3=O)c2cc1OC
InChI Key: InChIKey=BJPFHTCZRZBWRU-UHFFFAOYSA-N
PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24766 (5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Inhibition of recombinant c-met-mediated gastrin phosphorylation by HTRF assay | J Med Chem 55: 1858-67 (2012) Article DOI: 10.1021/jm201330u BindingDB Entry DOI: 10.7270/Q2ZK5HQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24766 (5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 63 | -9.72 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Amgen | Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ... | J Med Chem 51: 5766-79 (2008) Article DOI: 10.1021/jm8006189 BindingDB Entry DOI: 10.7270/Q23X84XN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24766 (5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 204 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Inhibition of HGF-mediated c-met autophosphorylation in serum-starved human PC3 cells after 1 hr by electrochemiluminescent immunoassay | J Med Chem 55: 1858-67 (2012) Article DOI: 10.1021/jm201330u BindingDB Entry DOI: 10.7270/Q2ZK5HQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24766 (5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of human c-MET | Eur J Med Chem 46: 3675-80 (2011) Article DOI: 10.1016/j.ejmech.2011.05.031 BindingDB Entry DOI: 10.7270/Q2891676 | |||||||||||
More data for this Ligand-Target Pair |