BDBM248919 US9434725, 150

SMILES: CCc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCCNCC1

InChI Key: InChIKey=ZAMFTNWEACEFAR-UHFFFAOYSA-N

Data: 3 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 248919   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM248919 (US9434725, 150) Show SMILES CCc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCCNCC1 Show InChI InChI=1S/C22H24N8/c1-2-17-14-24-15-19(27-17)18-11-20-16(12-25-18)13-26-30(20)22-6-3-5-21(28-22)29-9-4-7-23-8-10-29/h3,5-6,11-15,23H,2,4,7-10H2,1H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0190	-14.6	n/a	n/a	n/a	n/a	n/a	7.2	25
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM248919 (US9434725, 150) Show SMILES CCc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCCNCC1 Show InChI InChI=1S/C22H24N8/c1-2-17-14-24-15-19(27-17)18-11-20-16(12-25-18)13-26-30(20)22-6-3-5-21(28-22)29-9-4-7-23-8-10-29/h3,5-6,11-15,23H,2,4,7-10H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0210	-14.6	n/a	n/a	n/a	n/a	n/a	7.2	25
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM248919 (US9434725, 150) Show SMILES CCc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCCNCC1 Show InChI InChI=1S/C22H24N8/c1-2-17-14-24-15-19(27-17)18-11-20-16(12-25-18)13-26-30(20)22-6-3-5-21(28-22)29-9-4-7-23-8-10-29/h3,5-6,11-15,23H,2,4,7-10H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.333	-12.9	n/a	n/a	n/a	n/a	n/a	7.2	25
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Mus musculus (Mouse))	BDBM248919 (US9434725, 150) Show SMILES CCc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCCNCC1 Show InChI InChI=1S/C22H24N8/c1-2-17-14-24-15-19(27-17)18-11-20-16(12-25-18)13-26-30(20)22-6-3-5-21(28-22)29-9-4-7-23-8-10-29/h3,5-6,11-15,23H,2,4,7-10H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	196	n/a	n/a	n/a	n/a	n/a	n/a
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description BaF3, a murine interleukin-3 dependent pro-B cell line, parental cells, BaF3 PIM1 cells, BaF3 PIM2 cells, and MM1.S (multiple myeloma) cells were see...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair