BDBM248938 US9434725, 169::US9434725, 185::US9434725, 193

SMILES: CC1CN(CCN1)c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1

InChI Key: InChIKey=BVSPZNRNBYKDLE-UHFFFAOYSA-N

Data: 9 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 248938   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM248938 (US9434725, 169 | US9434725, 185 | US9434725, 193) Show SMILES CC1CN(CCN1)c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1 Show InChI InChI=1S/C21H22N8/c1-14-9-22-12-18(26-14)17-8-19-16(10-24-17)11-25-29(19)21-5-3-4-20(27-21)28-7-6-23-15(2)13-28/h3-5,8-12,15,23H,6-7,13H2,1-2H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0220	-14.5	n/a	n/a	n/a	n/a	n/a	7.2	25
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM248938 (US9434725, 169 | US9434725, 185 | US9434725, 193) Show SMILES CC1CN(CCN1)c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1 Show InChI InChI=1S/C21H22N8/c1-14-9-22-12-18(26-14)17-8-19-16(10-24-17)11-25-29(19)21-5-3-4-20(27-21)28-7-6-23-15(2)13-28/h3-5,8-12,15,23H,6-7,13H2,1-2H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0350	-14.3	n/a	n/a	n/a	n/a	n/a	7.2	25
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM248938 (US9434725, 169 | US9434725, 185 | US9434725, 193) Show SMILES CC1CN(CCN1)c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1 Show InChI InChI=1S/C21H22N8/c1-14-9-22-12-18(26-14)17-8-19-16(10-24-17)11-25-29(19)21-5-3-4-20(27-21)28-7-6-23-15(2)13-28/h3-5,8-12,15,23H,6-7,13H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0460	-14.1	n/a	n/a	n/a	n/a	n/a	7.2	25
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM248938 (US9434725, 169 | US9434725, 185 | US9434725, 193) Show SMILES CC1CN(CCN1)c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1 Show InChI InChI=1S/C21H22N8/c1-14-9-22-12-18(26-14)17-8-19-16(10-24-17)11-25-29(19)21-5-3-4-20(27-21)28-7-6-23-15(2)13-28/h3-5,8-12,15,23H,6-7,13H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0600	-13.9	n/a	n/a	n/a	n/a	n/a	7.2	25
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM248938 (US9434725, 169 | US9434725, 185 | US9434725, 193) Show SMILES CC1CN(CCN1)c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1 Show InChI InChI=1S/C21H22N8/c1-14-9-22-12-18(26-14)17-8-19-16(10-24-17)11-25-29(19)21-5-3-4-20(27-21)28-7-6-23-15(2)13-28/h3-5,8-12,15,23H,6-7,13H2,1-2H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.164	-13.3	n/a	n/a	n/a	n/a	n/a	7.2	25
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM248938 (US9434725, 169 | US9434725, 185 | US9434725, 193) Show SMILES CC1CN(CCN1)c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1 Show InChI InChI=1S/C21H22N8/c1-14-9-22-12-18(26-14)17-8-19-16(10-24-17)11-25-29(19)21-5-3-4-20(27-21)28-7-6-23-15(2)13-28/h3-5,8-12,15,23H,6-7,13H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.228	-13.1	n/a	n/a	n/a	n/a	n/a	7.2	25
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM248938 (US9434725, 169 | US9434725, 185 | US9434725, 193) Show SMILES CC1CN(CCN1)c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1 Show InChI InChI=1S/C21H22N8/c1-14-9-22-12-18(26-14)17-8-19-16(10-24-17)11-25-29(19)21-5-3-4-20(27-21)28-7-6-23-15(2)13-28/h3-5,8-12,15,23H,6-7,13H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.540	-12.6	n/a	n/a	n/a	n/a	n/a	7.2	25
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM248938 (US9434725, 169 | US9434725, 185 | US9434725, 193) Show SMILES CC1CN(CCN1)c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1 Show InChI InChI=1S/C21H22N8/c1-14-9-22-12-18(26-14)17-8-19-16(10-24-17)11-25-29(19)21-5-3-4-20(27-21)28-7-6-23-15(2)13-28/h3-5,8-12,15,23H,6-7,13H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.596	-12.6	n/a	n/a	n/a	n/a	n/a	7.2	25
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM248938 (US9434725, 169 | US9434725, 185 | US9434725, 193) Show SMILES CC1CN(CCN1)c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1 Show InChI InChI=1S/C21H22N8/c1-14-9-22-12-18(26-14)17-8-19-16(10-24-17)11-25-29(19)21-5-3-4-20(27-21)28-7-6-23-15(2)13-28/h3-5,8-12,15,23H,6-7,13H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.79	-11.9	n/a	n/a	n/a	n/a	n/a	7.2	25
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Mus musculus (Mouse))	BDBM248938 (US9434725, 169 | US9434725, 185 | US9434725, 193) Show SMILES CC1CN(CCN1)c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1 Show InChI InChI=1S/C21H22N8/c1-14-9-22-12-18(26-14)17-8-19-16(10-24-17)11-25-29(19)21-5-3-4-20(27-21)28-7-6-23-15(2)13-28/h3-5,8-12,15,23H,6-7,13H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	457	n/a	n/a	n/a	n/a	n/a	n/a
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description BaF3, a murine interleukin-3 dependent pro-B cell line, parental cells, BaF3 PIM1 cells, BaF3 PIM2 cells, and MM1.S (multiple myeloma) cells were see...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Mus musculus (Mouse))	BDBM248938 (US9434725, 169 | US9434725, 185 | US9434725, 193) Show SMILES CC1CN(CCN1)c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1 Show InChI InChI=1S/C21H22N8/c1-14-9-22-12-18(26-14)17-8-19-16(10-24-17)11-25-29(19)21-5-3-4-20(27-21)28-7-6-23-15(2)13-28/h3-5,8-12,15,23H,6-7,13H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description BaF3, a murine interleukin-3 dependent pro-B cell line, parental cells, BaF3 PIM1 cells, BaF3 PIM2 cells, and MM1.S (multiple myeloma) cells were see...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Mus musculus (Mouse))	BDBM248938 (US9434725, 169 | US9434725, 185 | US9434725, 193) Show SMILES CC1CN(CCN1)c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1 Show InChI InChI=1S/C21H22N8/c1-14-9-22-12-18(26-14)17-8-19-16(10-24-17)11-25-29(19)21-5-3-4-20(27-21)28-7-6-23-15(2)13-28/h3-5,8-12,15,23H,6-7,13H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description BaF3, a murine interleukin-3 dependent pro-B cell line, parental cells, BaF3 PIM1 cells, BaF3 PIM2 cells, and MM1.S (multiple myeloma) cells were see...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair