BDBM248950 US9434725, 181

SMILES: Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(C2CC2)c(n1)N1CCC[C@H](N)C1

InChI Key: InChIKey=OYVCFKLZLLYNOW-SFHVURJKSA-N

Data: 3 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 248950   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM248950 (US9434725, 181) Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(C2CC2)c(n1)N1CCC[C@H](N)C1 |r| Show InChI InChI=1S/C24H26N8/c1-15-10-26-13-21(29-15)20-9-22-17(11-27-20)12-28-32(22)23-7-6-19(16-4-5-16)24(30-23)31-8-2-3-18(25)14-31/h6-7,9-13,16,18H,2-5,8,14,25H2,1H3/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0140	-14.8	n/a	n/a	n/a	n/a	n/a	7.2	25
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM248950 (US9434725, 181) Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(C2CC2)c(n1)N1CCC[C@H](N)C1 |r| Show InChI InChI=1S/C24H26N8/c1-15-10-26-13-21(29-15)20-9-22-17(11-27-20)12-28-32(22)23-7-6-19(16-4-5-16)24(30-23)31-8-2-3-18(25)14-31/h6-7,9-13,16,18H,2-5,8,14,25H2,1H3/t18-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0190	-14.6	n/a	n/a	n/a	n/a	n/a	7.2	25
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM248950 (US9434725, 181) Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(C2CC2)c(n1)N1CCC[C@H](N)C1 |r| Show InChI InChI=1S/C24H26N8/c1-15-10-26-13-21(29-15)20-9-22-17(11-27-20)12-28-32(22)23-7-6-19(16-4-5-16)24(30-23)31-8-2-3-18(25)14-31/h6-7,9-13,16,18H,2-5,8,14,25H2,1H3/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0770	-13.8	n/a	n/a	n/a	n/a	n/a	7.2	25
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Mus musculus (Mouse))	BDBM248950 (US9434725, 181) Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(C2CC2)c(n1)N1CCC[C@H](N)C1 |r| Show InChI InChI=1S/C24H26N8/c1-15-10-26-13-21(29-15)20-9-22-17(11-27-20)12-28-32(22)23-7-6-19(16-4-5-16)24(30-23)31-8-2-3-18(25)14-31/h6-7,9-13,16,18H,2-5,8,14,25H2,1H3/t18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	214	n/a	n/a	n/a	n/a	n/a	n/a
F. HOFFMANN-LA ROCHE AG US Patent					Assay Description BaF3, a murine interleukin-3 dependent pro-B cell line, parental cells, BaF3 PIM1 cells, BaF3 PIM2 cells, and MM1.S (multiple myeloma) cells were see...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair