BDBM248970 US9434725, 201
SMILES: Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(C#N)c(n1)N1CCC[C@H](N)C1
InChI Key: InChIKey=OSJCCDKQCYGFSD-KRWDZBQOSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human)) | BDBM248970 (US9434725, 201) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0200 | -14.6 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
F. HOFFMANN-LA ROCHE AG US Patent | Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a... | US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM248970 (US9434725, 201) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0680 | -13.9 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
F. HOFFMANN-LA ROCHE AG US Patent | Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a... | US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human)) | BDBM248970 (US9434725, 201) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.286 | -13.0 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
F. HOFFMANN-LA ROCHE AG US Patent | Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a... | US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-1 (Mus musculus (Mouse)) | BDBM248970 (US9434725, 201) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
F. HOFFMANN-LA ROCHE AG US Patent | Assay Description BaF3, a murine interleukin-3 dependent pro-B cell line, parental cells, BaF3 PIM1 cells, BaF3 PIM2 cells, and MM1.S (multiple myeloma) cells were see... | US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N | |||||||||||
More data for this Ligand-Target Pair |