BDBM249134 US9453038, 10
SMILES: COC(=O)CCc1ccc(nc1)-c1cc2cc(Oc3ccc(nc3)C(=O)N3CCC3)c(cc2[nH]1)C1CCCN1C(C)=O
InChI Key:
Data: 1 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glucokinase/Glucokinase regulatory protein (Homo sapiens (Human)) | BDBM249134 (US9453038, 10) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 13.9 | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description To test the exemplified compounds, the following assay was employed. Recombinant human liver glucokinase was expressed as a FLAG fusion protein in E.... | US Patent US9453038 (2016) BindingDB Entry DOI: 10.7270/Q23X85KK | |||||||||||
More data for this Ligand-Target Pair |