BDBM249278 US10017501, Compound 1020-19::US9458145, 1020-19

SMILES: Cc1noc(C)c1-c1cc(-c2cccnc2-c2ccccc2)c2nc([nH]c2c1)C1CC1

InChI Key: InChIKey=ZTTDZAWIKNDGPB-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 249278   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) (Homo sapiens (Human))	BDBM249278 (US10017501, Compound 1020-19 | US9458145, 1020-19) Show SMILES Cc1noc(C)c1-c1cc(-c2cccnc2-c2ccccc2)c2nc([nH]c2c1)C1CC1 Show InChI InChI=1S/C26H22N4O/c1-15-23(16(2)31-30-15)19-13-21(25-22(14-19)28-26(29-25)18-10-11-18)20-9-6-12-27-24(20)17-7-4-3-5-8-17/h3-9,12-14,18H,10-11H2,1-2H3,(H,28,29)	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	134	n/a	n/a	n/a	n/a	7.5	25
Gilead Sciences, Inc. US Patent					Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...				US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) (Homo sapiens (Human))	BDBM249278 (US10017501, Compound 1020-19 | US9458145, 1020-19) Show SMILES Cc1noc(C)c1-c1cc(-c2cccnc2-c2ccccc2)c2nc([nH]c2c1)C1CC1 Show InChI InChI=1S/C26H22N4O/c1-15-23(16(2)31-30-15)19-13-21(25-22(14-19)28-26(29-25)18-10-11-18)20-9-6-12-27-24(20)17-7-4-3-5-8-17/h3-9,12-14,18H,10-11H2,1-2H3,(H,28,29)	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	172	n/a	n/a	n/a	n/a	7.5	25
Gilead Sciences, Inc. US Patent					Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...				US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) (Homo sapiens (Human))	BDBM249278 (US10017501, Compound 1020-19 | US9458145, 1020-19) Show SMILES Cc1noc(C)c1-c1cc(-c2cccnc2-c2ccccc2)c2nc([nH]c2c1)C1CC1 Show InChI InChI=1S/C26H22N4O/c1-15-23(16(2)31-30-15)19-13-21(25-22(14-19)28-26(29-25)18-10-11-18)20-9-6-12-27-24(20)17-7-4-3-5-8-17/h3-9,12-14,18H,10-11H2,1-2H3,(H,28,29)	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	172	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences Inc US Patent					Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...				US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) (Homo sapiens (Human))	BDBM249278 (US10017501, Compound 1020-19 | US9458145, 1020-19) Show SMILES Cc1noc(C)c1-c1cc(-c2cccnc2-c2ccccc2)c2nc([nH]c2c1)C1CC1 Show InChI InChI=1S/C26H22N4O/c1-15-23(16(2)31-30-15)19-13-21(25-22(14-19)28-26(29-25)18-10-11-18)20-9-6-12-27-24(20)17-7-4-3-5-8-17/h3-9,12-14,18H,10-11H2,1-2H3,(H,28,29)	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	134	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences Inc US Patent					Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...				US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) (Homo sapiens (Human))	BDBM249278 (US10017501, Compound 1020-19 | US9458145, 1020-19) Show SMILES Cc1noc(C)c1-c1cc(-c2cccnc2-c2ccccc2)c2nc([nH]c2c1)C1CC1 Show InChI InChI=1S/C26H22N4O/c1-15-23(16(2)31-30-15)19-13-21(25-22(14-19)28-26(29-25)18-10-11-18)20-9-6-12-27-24(20)17-7-4-3-5-8-17/h3-9,12-14,18H,10-11H2,1-2H3,(H,28,29)	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	7.5	25
Gilead Sciences, Inc. US Patent					Assay Description Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...				US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53
					More data for this Ligand-Target Pair