BDBM249290 US10017501, Compound 1020-81::US9458145, 1020-81
SMILES: Cc1n[nH]c(C)c1-c1cc(cc2[nH]c(NC3CC3)nc12)-c1c(C)noc1C
InChI Key: InChIKey=CPQRZDPSADFJEU-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) (Homo sapiens (Human)) | BDBM249290 (US10017501, Compound 1020-81 | US9458145, 1020-81) | GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 169 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Gilead Sciences, Inc. US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) (Homo sapiens (Human)) | BDBM249290 (US10017501, Compound 1020-81 | US9458145, 1020-81) | GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 119 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Gilead Sciences, Inc. US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) (Homo sapiens (Human)) | BDBM249290 (US10017501, Compound 1020-81 | US9458145, 1020-81) | GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 119 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) (Homo sapiens (Human)) | BDBM249290 (US10017501, Compound 1020-81 | US9458145, 1020-81) | GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 169 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) (Homo sapiens (Human)) | BDBM249290 (US10017501, Compound 1020-81 | US9458145, 1020-81) | GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 50.7 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Gilead Sciences, Inc. US Patent | Assay Description Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass... | US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53 | |||||||||||
More data for this Ligand-Target Pair |