BDBM249292 US10017501, Compound 1020-88::US9458145, 1020-88

SMILES: Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2nc([nH]c2c1)-c1cnn(C)c1

InChI Key: InChIKey=VKCISKKMCAGVPR-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 249292   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 [75-147] (Homo sapiens (Human))	BDBM249292 (US10017501, Compound 1020-88 | US9458145, 1020-88) Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2nc([nH]c2c1)-c1cnn(C)c1 |(2.9,3.95,;1.56,4.72,;1.09,6.18,;-.45,6.18,;-.93,4.72,;-2.26,3.95,;.32,3.81,;.32,2.27,;1.65,1.5,;1.65,-.04,;2.99,-.81,;4.32,-.04,;4.32,1.5,;5.65,-.81,;5.65,-2.35,;4.32,-3.12,;4.32,-4.66,;2.99,-5.43,;1.65,-4.66,;1.65,-3.12,;2.99,-2.35,;.32,-.81,;-0,-2.32,;-1.53,-2.48,;-2.16,-1.07,;-1.02,-.04,;-1.02,1.5,;-2.3,-3.81,;-1.83,-5.28,;-3.07,-6.18,;-4.32,-5.28,;-5.65,-6.05,;-3.84,-3.81,)| Show InChI InChI=1S/C26H22N6O/c1-14-7-8-21-19(6-5-9-27-21)23(14)20-10-17(24-15(2)31-33-16(24)3)11-22-25(20)30-26(29-22)18-12-28-32(4)13-18/h5-13H,1-4H3,(H,29,30)	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	104	n/a	n/a	n/a	n/a	7.5	25
Gilead Sciences, Inc. US Patent					Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...				US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human))	BDBM249292 (US10017501, Compound 1020-88 | US9458145, 1020-88) Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2nc([nH]c2c1)-c1cnn(C)c1 |(2.9,3.95,;1.56,4.72,;1.09,6.18,;-.45,6.18,;-.93,4.72,;-2.26,3.95,;.32,3.81,;.32,2.27,;1.65,1.5,;1.65,-.04,;2.99,-.81,;4.32,-.04,;4.32,1.5,;5.65,-.81,;5.65,-2.35,;4.32,-3.12,;4.32,-4.66,;2.99,-5.43,;1.65,-4.66,;1.65,-3.12,;2.99,-2.35,;.32,-.81,;-0,-2.32,;-1.53,-2.48,;-2.16,-1.07,;-1.02,-.04,;-1.02,1.5,;-2.3,-3.81,;-1.83,-5.28,;-3.07,-6.18,;-4.32,-5.28,;-5.65,-6.05,;-3.84,-3.81,)| Show InChI InChI=1S/C26H22N6O/c1-14-7-8-21-19(6-5-9-27-21)23(14)20-10-17(24-15(2)31-33-16(24)3)11-22-25(20)30-26(29-22)18-12-28-32(4)13-18/h5-13H,1-4H3,(H,29,30)	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	131	n/a	n/a	n/a	n/a	7.5	25
Gilead Sciences, Inc. US Patent					Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...				US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human))	BDBM249292 (US10017501, Compound 1020-88 | US9458145, 1020-88) Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2nc([nH]c2c1)-c1cnn(C)c1 |(2.9,3.95,;1.56,4.72,;1.09,6.18,;-.45,6.18,;-.93,4.72,;-2.26,3.95,;.32,3.81,;.32,2.27,;1.65,1.5,;1.65,-.04,;2.99,-.81,;4.32,-.04,;4.32,1.5,;5.65,-.81,;5.65,-2.35,;4.32,-3.12,;4.32,-4.66,;2.99,-5.43,;1.65,-4.66,;1.65,-3.12,;2.99,-2.35,;.32,-.81,;-0,-2.32,;-1.53,-2.48,;-2.16,-1.07,;-1.02,-.04,;-1.02,1.5,;-2.3,-3.81,;-1.83,-5.28,;-3.07,-6.18,;-4.32,-5.28,;-5.65,-6.05,;-3.84,-3.81,)| Show InChI InChI=1S/C26H22N6O/c1-14-7-8-21-19(6-5-9-27-21)23(14)20-10-17(24-15(2)31-33-16(24)3)11-22-25(20)30-26(29-22)18-12-28-32(4)13-18/h5-13H,1-4H3,(H,29,30)	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	131	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences Inc US Patent					Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...				US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [75-147] (Homo sapiens (Human))	BDBM249292 (US10017501, Compound 1020-88 | US9458145, 1020-88) Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2nc([nH]c2c1)-c1cnn(C)c1 |(2.9,3.95,;1.56,4.72,;1.09,6.18,;-.45,6.18,;-.93,4.72,;-2.26,3.95,;.32,3.81,;.32,2.27,;1.65,1.5,;1.65,-.04,;2.99,-.81,;4.32,-.04,;4.32,1.5,;5.65,-.81,;5.65,-2.35,;4.32,-3.12,;4.32,-4.66,;2.99,-5.43,;1.65,-4.66,;1.65,-3.12,;2.99,-2.35,;.32,-.81,;-0,-2.32,;-1.53,-2.48,;-2.16,-1.07,;-1.02,-.04,;-1.02,1.5,;-2.3,-3.81,;-1.83,-5.28,;-3.07,-6.18,;-4.32,-5.28,;-5.65,-6.05,;-3.84,-3.81,)| Show InChI InChI=1S/C26H22N6O/c1-14-7-8-21-19(6-5-9-27-21)23(14)20-10-17(24-15(2)31-33-16(24)3)11-22-25(20)30-26(29-22)18-12-28-32(4)13-18/h5-13H,1-4H3,(H,29,30)	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	104	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences Inc US Patent					Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...				US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [75-147] (Homo sapiens (Human))	BDBM249292 (US10017501, Compound 1020-88 | US9458145, 1020-88) Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2nc([nH]c2c1)-c1cnn(C)c1 |(2.9,3.95,;1.56,4.72,;1.09,6.18,;-.45,6.18,;-.93,4.72,;-2.26,3.95,;.32,3.81,;.32,2.27,;1.65,1.5,;1.65,-.04,;2.99,-.81,;4.32,-.04,;4.32,1.5,;5.65,-.81,;5.65,-2.35,;4.32,-3.12,;4.32,-4.66,;2.99,-5.43,;1.65,-4.66,;1.65,-3.12,;2.99,-2.35,;.32,-.81,;-0,-2.32,;-1.53,-2.48,;-2.16,-1.07,;-1.02,-.04,;-1.02,1.5,;-2.3,-3.81,;-1.83,-5.28,;-3.07,-6.18,;-4.32,-5.28,;-5.65,-6.05,;-3.84,-3.81,)| Show InChI InChI=1S/C26H22N6O/c1-14-7-8-21-19(6-5-9-27-21)23(14)20-10-17(24-15(2)31-33-16(24)3)11-22-25(20)30-26(29-22)18-12-28-32(4)13-18/h5-13H,1-4H3,(H,29,30)	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.9	n/a	n/a	n/a	n/a	7.5	25
Gilead Sciences, Inc. US Patent					Assay Description Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...				US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53
					More data for this Ligand-Target Pair