BDBM249294 US10017501, Compound 1020-90::US9458145, 1020-90

SMILES: COc1nc2c(cc(cc2[nH]1)-c1c(C)noc1C)-c1c(C)ccc2ncccc12

InChI Key: InChIKey=ZHSYNUAULROSRV-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 249294   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) (Homo sapiens (Human))	BDBM249294 (US10017501, Compound 1020-90 | US9458145, 1020-90) Show SMILES COc1nc2c(cc(cc2[nH]1)-c1c(C)noc1C)-c1c(C)ccc2ncccc12 |(-5.25,-5,;-3.71,-5,;-2.94,-3.66,;-1.41,-3.5,;-1.09,-1.99,;.25,-1.22,;.25,.32,;-1.09,1.09,;-2.42,.32,;-2.42,-1.22,;-3.56,-2.25,;-1.09,2.63,;.16,3.53,;1.49,2.76,;-.32,5,;-1.86,5,;-2.33,3.53,;-3.67,2.76,;1.58,-1.99,;1.98,-3.48,;.89,-4.57,;3.47,-3.88,;4.56,-2.79,;4.16,-1.3,;5.25,-.22,;4.85,1.27,;3.36,1.67,;2.27,.58,;2.67,-.91,)| Show InChI InChI=1S/C23H20N4O2/c1-12-7-8-18-16(6-5-9-24-18)20(12)17-10-15(21-13(2)27-29-14(21)3)11-19-22(17)26-23(25-19)28-4/h5-11H,1-4H3,(H,25,26)	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	110	n/a	n/a	n/a	n/a	7.5	25
Gilead Sciences, Inc. US Patent					Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...				US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) (Homo sapiens (Human))	BDBM249294 (US10017501, Compound 1020-90 | US9458145, 1020-90) Show SMILES COc1nc2c(cc(cc2[nH]1)-c1c(C)noc1C)-c1c(C)ccc2ncccc12 |(-5.25,-5,;-3.71,-5,;-2.94,-3.66,;-1.41,-3.5,;-1.09,-1.99,;.25,-1.22,;.25,.32,;-1.09,1.09,;-2.42,.32,;-2.42,-1.22,;-3.56,-2.25,;-1.09,2.63,;.16,3.53,;1.49,2.76,;-.32,5,;-1.86,5,;-2.33,3.53,;-3.67,2.76,;1.58,-1.99,;1.98,-3.48,;.89,-4.57,;3.47,-3.88,;4.56,-2.79,;4.16,-1.3,;5.25,-.22,;4.85,1.27,;3.36,1.67,;2.27,.58,;2.67,-.91,)| Show InChI InChI=1S/C23H20N4O2/c1-12-7-8-18-16(6-5-9-24-18)20(12)17-10-15(21-13(2)27-29-14(21)3)11-19-22(17)26-23(25-19)28-4/h5-11H,1-4H3,(H,25,26)	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	121	n/a	n/a	n/a	n/a	7.5	25
Gilead Sciences, Inc. US Patent					Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...				US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) (Homo sapiens (Human))	BDBM249294 (US10017501, Compound 1020-90 | US9458145, 1020-90) Show SMILES COc1nc2c(cc(cc2[nH]1)-c1c(C)noc1C)-c1c(C)ccc2ncccc12 |(-5.25,-5,;-3.71,-5,;-2.94,-3.66,;-1.41,-3.5,;-1.09,-1.99,;.25,-1.22,;.25,.32,;-1.09,1.09,;-2.42,.32,;-2.42,-1.22,;-3.56,-2.25,;-1.09,2.63,;.16,3.53,;1.49,2.76,;-.32,5,;-1.86,5,;-2.33,3.53,;-3.67,2.76,;1.58,-1.99,;1.98,-3.48,;.89,-4.57,;3.47,-3.88,;4.56,-2.79,;4.16,-1.3,;5.25,-.22,;4.85,1.27,;3.36,1.67,;2.27,.58,;2.67,-.91,)| Show InChI InChI=1S/C23H20N4O2/c1-12-7-8-18-16(6-5-9-24-18)20(12)17-10-15(21-13(2)27-29-14(21)3)11-19-22(17)26-23(25-19)28-4/h5-11H,1-4H3,(H,25,26)	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	121	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences Inc US Patent					Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...				US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) (Homo sapiens (Human))	BDBM249294 (US10017501, Compound 1020-90 | US9458145, 1020-90) Show SMILES COc1nc2c(cc(cc2[nH]1)-c1c(C)noc1C)-c1c(C)ccc2ncccc12 |(-5.25,-5,;-3.71,-5,;-2.94,-3.66,;-1.41,-3.5,;-1.09,-1.99,;.25,-1.22,;.25,.32,;-1.09,1.09,;-2.42,.32,;-2.42,-1.22,;-3.56,-2.25,;-1.09,2.63,;.16,3.53,;1.49,2.76,;-.32,5,;-1.86,5,;-2.33,3.53,;-3.67,2.76,;1.58,-1.99,;1.98,-3.48,;.89,-4.57,;3.47,-3.88,;4.56,-2.79,;4.16,-1.3,;5.25,-.22,;4.85,1.27,;3.36,1.67,;2.27,.58,;2.67,-.91,)| Show InChI InChI=1S/C23H20N4O2/c1-12-7-8-18-16(6-5-9-24-18)20(12)17-10-15(21-13(2)27-29-14(21)3)11-19-22(17)26-23(25-19)28-4/h5-11H,1-4H3,(H,25,26)	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences Inc US Patent					Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...				US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) (Homo sapiens (Human))	BDBM249294 (US10017501, Compound 1020-90 | US9458145, 1020-90) Show SMILES COc1nc2c(cc(cc2[nH]1)-c1c(C)noc1C)-c1c(C)ccc2ncccc12 |(-5.25,-5,;-3.71,-5,;-2.94,-3.66,;-1.41,-3.5,;-1.09,-1.99,;.25,-1.22,;.25,.32,;-1.09,1.09,;-2.42,.32,;-2.42,-1.22,;-3.56,-2.25,;-1.09,2.63,;.16,3.53,;1.49,2.76,;-.32,5,;-1.86,5,;-2.33,3.53,;-3.67,2.76,;1.58,-1.99,;1.98,-3.48,;.89,-4.57,;3.47,-3.88,;4.56,-2.79,;4.16,-1.3,;5.25,-.22,;4.85,1.27,;3.36,1.67,;2.27,.58,;2.67,-.91,)| Show InChI InChI=1S/C23H20N4O2/c1-12-7-8-18-16(6-5-9-24-18)20(12)17-10-15(21-13(2)27-29-14(21)3)11-19-22(17)26-23(25-19)28-4/h5-11H,1-4H3,(H,25,26)	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29.9	n/a	n/a	n/a	n/a	7.5	25
Gilead Sciences, Inc. US Patent					Assay Description Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...				US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53
					More data for this Ligand-Target Pair