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BDBM249311 US10017501, Compound 1020-239::US9458145, 1020-239

SMILES: Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccn1)c1ncccn1

InChI Key:

Data: 2 KI 2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 249311
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) (Homo sapiens (Human))	BDBM249311 (US10017501, Compound 1020-239 \| US9458145, 1020-23...) Show SMILES Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences Inc US Patent					Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...				US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z
Gilead Sciences Inc US Patent					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) (Homo sapiens (Human))	BDBM249311 (US10017501, Compound 1020-239 \| US9458145, 1020-23...) Show SMILES Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences Inc US Patent					Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...				US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z
Gilead Sciences Inc US Patent					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) (Homo sapiens (Human))	BDBM249311 (US10017501, Compound 1020-239 \| US9458145, 1020-23...) Show SMILES Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.90	n/a	n/a	n/a	n/a	7.5	25
Gilead Sciences, Inc. US Patent					Assay Description The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi...				US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53
Gilead Sciences, Inc. US Patent					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) (Homo sapiens (Human))	BDBM249311 (US10017501, Compound 1020-239 \| US9458145, 1020-23...) Show SMILES Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	25
Gilead Sciences, Inc. US Patent					Assay Description The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi...				US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53
Gilead Sciences, Inc. US Patent					More data for this Ligand-Target Pair