BDBM24941 (2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methylidene}-3-oxobutanenitrile::CHEMBL228043::LFM-A13::Thr1 inhibitor, 2::alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl)propenamide
SMILES: CC(=O)C(C#N)C(=O)Nc1cc(Br)ccc1Br
InChI Key: InChIKey=BQLDGDMKDYAGNE-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Polo-Like Kinase 3 (Homo sapiens (Human)) | BDBM24941 ((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...) | PDB NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 7.20E+3 | -6.94 | 6.10E+4 | n/a | n/a | n/a | n/a | 7.0 | 22 |
Paradigm Pharmaceuticals | Assay Description The mode of human PLK3 inhibition by LFM-A13 was examined in titration experiments using increasing concentrations of [gamma-32P]ATP and purified N-t... | Bioorg Med Chem 15: 800-14 (2007) Article DOI: 10.1016/j.bmc.2006.10.050 BindingDB Entry DOI: 10.7270/Q2Z60MCR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Homoserine kinase (Escherichia coli) | BDBM24941 ((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 1.20E+4 | -6.98 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
McMaster University | Assay Description The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o... | Chembiochem 12: 1179-82 (2011) Article DOI: 10.1002/cbic.201100121 BindingDB Entry DOI: 10.7270/Q24T6GWV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Dependent Kinase 2 (CDK2) (Homo sapiens (Human)) | BDBM24941 ((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Paradigm Pharmaceuticals | Assay Description The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay... | Bioorg Med Chem 15: 800-14 (2007) Article DOI: 10.1016/j.bmc.2006.10.050 BindingDB Entry DOI: 10.7270/Q2Z60MCR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM24941 ((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Paradigm Pharmaceuticals | Assay Description The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay... | Bioorg Med Chem 15: 800-14 (2007) Article DOI: 10.1016/j.bmc.2006.10.050 BindingDB Entry DOI: 10.7270/Q2Z60MCR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BRK (Homo sapiens (Human)) | BDBM24941 ((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.67E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Paradigm Pharmaceuticals | Assay Description The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay... | Bioorg Med Chem 15: 800-14 (2007) Article DOI: 10.1016/j.bmc.2006.10.050 BindingDB Entry DOI: 10.7270/Q2Z60MCR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytoplasmic tyrosine-protein kinase BMX (Homo sapiens (Human)) | BDBM24941 ((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.81E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Paradigm Pharmaceuticals | Assay Description The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay... | Bioorg Med Chem 15: 800-14 (2007) Article DOI: 10.1016/j.bmc.2006.10.050 BindingDB Entry DOI: 10.7270/Q2Z60MCR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM24941 ((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant BTK expressed in baculovirus expression vector system | J Med Chem 55: 4539-50 (2012) Article DOI: 10.1021/jm300035p BindingDB Entry DOI: 10.7270/Q27H1KMF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM24941 ((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Paradigm Pharmaceuticals | Assay Description The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay... | Bioorg Med Chem 15: 800-14 (2007) Article DOI: 10.1016/j.bmc.2006.10.050 BindingDB Entry DOI: 10.7270/Q2Z60MCR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24941 ((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.15E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Paradigm Pharmaceuticals | Assay Description The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay... | Bioorg Med Chem 15: 800-14 (2007) Article DOI: 10.1016/j.bmc.2006.10.050 BindingDB Entry DOI: 10.7270/Q2Z60MCR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM24941 ((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.72E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford Curated by ChEMBL | Assay Description Inhibition of human BTK | Proc Natl Acad Sci USA 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM24941 ((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford Curated by ChEMBL | Assay Description Inhibition of recombinant BTK | Proc Natl Acad Sci USA 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PLK3 (Homo sapiens (Human)) | BDBM24941 ((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...) | PDB NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford Curated by ChEMBL | Assay Description Inhibition of Plk3 | Proc Natl Acad Sci USA 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM24941 ((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Molecular Physiology Curated by ChEMBL | Assay Description Inhibition of BTK | Bioorg Med Chem 17: 1079-87 (2009) Article DOI: 10.1016/j.bmc.2008.02.046 BindingDB Entry DOI: 10.7270/Q2M046C4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Dependent Kinase 1 (CDK1) (Homo sapiens (Human)) | BDBM24941 ((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Paradigm Pharmaceuticals | Assay Description The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay... | Bioorg Med Chem 15: 800-14 (2007) Article DOI: 10.1016/j.bmc.2006.10.050 BindingDB Entry DOI: 10.7270/Q2Z60MCR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polo-Like Kinase 1 (Xenopus laevis) | BDBM24941 ((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Paradigm Pharmaceuticals | Assay Description Purified Plx1 was first incubated with different concentrations of LFM-A13. The substrate, GST-Cdc25 peptide (254-316) and [gamma-32P]ATP were added ... | Bioorg Med Chem 15: 800-14 (2007) Article DOI: 10.1016/j.bmc.2006.10.050 BindingDB Entry DOI: 10.7270/Q2Z60MCR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Fyn (Homo sapiens (Human)) | BDBM24941 ((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Paradigm Pharmaceuticals | Assay Description The specificity of LFM-A13 was further examined against a broad panel of serine-threonine kinases and tyrosine kinases using the KinaseProfiler Assay... | Bioorg Med Chem 15: 800-14 (2007) Article DOI: 10.1016/j.bmc.2006.10.050 BindingDB Entry DOI: 10.7270/Q2Z60MCR | |||||||||||
More data for this Ligand-Target Pair |