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BDBM249513 US10072016, Compound 111::US10407433, Compound 111::US10913746, Compound 111::US9434727, 111::US9777010, Compound 111
SMILES: CCN1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1ccc(F)c(F)c1C(F)(F)F
InChI Key: InChIKey=LXRKRDSCUQHHSE-UHFFFAOYSA-N
Data: 7 IC50
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Retinol-binding protein 4 (Homo sapiens (Human)) | BDBM249513 (US10072016, Compound 111 | US10407433, Compound 11...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.89 | n/a | n/a | n/a | n/a | 7.4 | 4 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK US Patent | Assay Description Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u... | US Patent US9434727 (2016) BindingDB Entry DOI: 10.7270/Q2F76BGR | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Retinol-binding protein 4 (Homo sapiens (Human)) | BDBM249513 (US10072016, Compound 111 | US10407433, Compound 11...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 22.1 | n/a | n/a | n/a | n/a | 7.5 | 4 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK US Patent | Assay Description TR-FRET assay for retinol-induced RBP4-TTR interaction Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR inte... | US Patent US9434727 (2016) BindingDB Entry DOI: 10.7270/Q2F76BGR | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Retinol-binding protein 4 (Homo sapiens (Human)) | BDBM249513 (US10072016, Compound 111 | US10407433, Compound 11...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.89 | n/a | n/a | n/a | n/a | 7.5 | n/a |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK US Patent | Assay Description Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7)... | US Patent US10072016 (2018) BindingDB Entry DOI: 10.7270/Q2QJ7KBT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Retinol-binding protein 4 (Homo sapiens (Human)) | BDBM249513 (US10072016, Compound 111 | US10407433, Compound 11...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.89 | n/a | n/a | n/a | n/a | n/a | n/a |
The Trustees of Columbia University in the City of New York US Patent | Assay Description Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u... | US Patent US10913746 (2021) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Retinol-binding protein 4 (Homo sapiens (Human)) | BDBM249513 (US10072016, Compound 111 | US10407433, Compound 11...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.89 | n/a | n/a | n/a | n/a | n/a | n/a |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK US Patent | Assay Description Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u... | US Patent US9777010 (2017) BindingDB Entry DOI: 10.7270/Q22J6F0D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Retinol-binding protein 4 (Homo sapiens (Human)) | BDBM249513 (US10072016, Compound 111 | US10407433, Compound 11...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.89 | n/a | n/a | n/a | n/a | n/a | n/a |
The Trustees of Columbia University In The City of New York US Patent | Assay Description Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u... | US Patent US10407433 (2019) BindingDB Entry DOI: 10.7270/Q2W95CKV | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Transthyretin (Homo sapiens (Human)) | BDBM249513 (US10072016, Compound 111 | US10407433, Compound 11...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 22.1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK US Patent | Assay Description Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u... | US Patent US10072016 (2018) BindingDB Entry DOI: 10.7270/Q2QJ7KBT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
