BDBM24984 (5E)-1-(3,5-dimethylphenyl)-5-[(5-phenylfuran-2-yl)methylidene]-1,3-diazinane-2,4,6-trione::5-(furan-2-ylmethylene) pyrimidine-2,4,6-trione derivative, 1
SMILES: Cc1cc(C)cc(c1)N1C(=O)NC(=O)C(=Cc2ccc(o2)-c2ccccc2)C1=O
InChI Key: InChIKey=QGFJVFPBNBXCRV-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fatty acid synthase (Homo sapiens (Human)) | BDBM24984 ((5E)-1-(3,5-dimethylphenyl)-5-[(5-phenylfuran-2-yl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Antagonist activity at human recombinant FASN thioesterase domain by fluorigenic assay | J Med Chem 54: 5615-38 (2011) Article DOI: 10.1021/jm2005805 BindingDB Entry DOI: 10.7270/Q21N8261 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty Acid Synthase (Homo sapiens (Human)) | BDBM24984 ((5E)-1-(3,5-dimethylphenyl)-5-[(5-phenylfuran-2-yl...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 380 | -9.10 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
Burnham Institute for Medical Research | Assay Description The reaction mixture consisted of FAS thioesterase domain (FASTE) in buffer, which was preincubated with test compounds for 30 min. The reaction was ... | Mol Cancer Ther 6: 2120-6 (2007) Article DOI: 10.1158/1535-7163.MCT-07-0187 BindingDB Entry DOI: 10.7270/Q2F769V8 | |||||||||||
More data for this Ligand-Target Pair |