BDBM25056 4-{6-chloroimidazo[1,2-a]pyridin-3-yl}-2-[(2-methyl-5-nitrobenzene)sulfonyl]-1,3-thiazole::imidazo[1,2-a]pyridine derivative, 12
SMILES: Cc1ccc(cc1S(=O)(=O)c1nc(cs1)-c1cnc2ccc(Cl)cn12)[N+]([O-])=O
InChI Key: InChIKey=WRDUSFKPZVPYTB-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM25056 (4-{6-chloroimidazo[1,2-a]pyridin-3-yl}-2-[(2-methy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Astellas Pharma Inc. | Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft... | Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens (Human)) | BDBM25056 (4-{6-chloroimidazo[1,2-a]pyridin-3-yl}-2-[(2-methy...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Astellas Pharma Inc. | Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft... | Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human)) | BDBM25056 (4-{6-chloroimidazo[1,2-a]pyridin-3-yl}-2-[(2-methy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 230 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Astellas Pharma Inc. | Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft... | Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human)) | BDBM25056 (4-{6-chloroimidazo[1,2-a]pyridin-3-yl}-2-[(2-methy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Astellas Pharma Inc. | Assay Description The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft... | Bioorg Med Chem 15: 403-12 (2007) Article DOI: 10.1016/j.bmc.2006.09.047 BindingDB Entry DOI: 10.7270/Q2SJ1HXZ | |||||||||||
More data for this Ligand-Target Pair |