BDBM25058 (5Z)-5-[(3-hydroxy-5-methoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one::Compound I, rhodanine

SMILES: COc1cc(O)cc(\C=C2/SC(=S)NC2=O)c1

InChI Key: InChIKey=LSVTZBNOOSOZLV-WTKPLQERSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 25058   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM25058 ((5Z)-5-[(3-hydroxy-5-methoxyphenyl)methylidene]-2-...) Show SMILES COc1cc(O)cc(\C=C2/SC(=S)NC2=O)c1 Show InChI InChI=1S/C11H9NO3S2/c1-15-8-3-6(2-7(13)5-8)4-9-10(14)12-11(16)17-9/h2-5,13H,1H3,(H,12,14,16)/b9-4-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	328	n/a	n/a	n/a	n/a	n/a	n/a
The University of Jordan Curated by ChEMBL					Assay Description Inhibition of PI3Kgamma (unknown origin) assessed as decrease in fluorescence intensity using phosphorylated substrate				Eur J Med Chem 84: 454-65 (2014) Article DOI: 10.1016/j.ejmech.2014.07.056 BindingDB Entry DOI: 10.7270/Q2057HM8
					More data for this Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma (Homo sapiens (Human))	BDBM25058 ((5Z)-5-[(3-hydroxy-5-methoxyphenyl)methylidene]-2-...) Show SMILES COc1cc(O)cc(\C=C2/SC(=S)NC2=O)c1 Show InChI InChI=1S/C11H9NO3S2/c1-15-8-3-6(2-7(13)5-8)4-9-10(14)12-11(16)17-9/h2-5,13H,1H3,(H,12,14,16)/b9-4-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	77.7	n/a	n/a	n/a	n/a	7.4	30
Pfizer					Assay Description PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...				Bioorg Med Chem Lett 17: 756-60 (2007) Article DOI: 10.1016/j.bmcl.2006.10.080 BindingDB Entry DOI: 10.7270/Q2NS0S6N
					More data for this Ligand-Target Pair