BDBM25082 3-(2,4-diamino-pteridin-6-yl)-phenol::3-(2,4-diaminopteridin-6-yl)phenol::JMC504279 Compound 17::TG100713

SMILES: Nc1nc(N)c2nc(cnc2n1)-c1cccc(O)c1

InChI Key: InChIKey=UOORQSPLBHUQDQ-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 25082   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM25082 (3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...) Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1cccc(O)c1 Show InChI InChI=1S/C12H10N6O/c13-10-9-11(18-12(14)17-10)15-5-8(16-9)6-2-1-3-7(19)4-6/h1-5,19H,(H4,13,14,15,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	7.4	22
TargeGen Inc.					Assay Description The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...				Proc Natl Acad Sci U S A 103: 19866-71 (2006) Article DOI: 10.1073/pnas.0606956103 BindingDB Entry DOI: 10.7270/Q2J101GM
					More data for this Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), delta (Homo sapiens (Human))	BDBM25082 (3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...) Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1cccc(O)c1 Show InChI InChI=1S/C12H10N6O/c13-10-9-11(18-12(14)17-10)15-5-8(16-9)6-2-1-3-7(19)4-6/h1-5,19H,(H4,13,14,15,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	7.4	22
TargeGen Inc.					Assay Description The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...				Proc Natl Acad Sci U S A 103: 19866-71 (2006) Article DOI: 10.1073/pnas.0606956103 BindingDB Entry DOI: 10.7270/Q2J101GM
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM25082 (3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...) Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1cccc(O)c1 Show InChI InChI=1S/C12H10N6O/c13-10-9-11(18-12(14)17-10)15-5-8(16-9)6-2-1-3-7(19)4-6/h1-5,19H,(H4,13,14,15,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	39.9	n/a	n/a	n/a	n/a	7.4	22
TargeGen Inc.					Assay Description The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...				J Med Chem 50: 4279-94 (2007) Article DOI: 10.1021/jm051056c BindingDB Entry DOI: 10.7270/Q2D798QW
					More data for this Ligand-Target Pair
p110β/p85α (Homo sapiens (Human))	BDBM25082 (3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...) Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1cccc(O)c1 Show InChI InChI=1S/C12H10N6O/c13-10-9-11(18-12(14)17-10)15-5-8(16-9)6-2-1-3-7(19)4-6/h1-5,19H,(H4,13,14,15,17,18)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	215	n/a	n/a	n/a	n/a	7.4	22
TargeGen Inc.					Assay Description The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...				Proc Natl Acad Sci U S A 103: 19866-71 (2006) Article DOI: 10.1073/pnas.0606956103 BindingDB Entry DOI: 10.7270/Q2J101GM
					More data for this Ligand-Target Pair
p110α/p85α (Homo sapiens (Human))	BDBM25082 (3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...) Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1cccc(O)c1 Show InChI InChI=1S/C12H10N6O/c13-10-9-11(18-12(14)17-10)15-5-8(16-9)6-2-1-3-7(19)4-6/h1-5,19H,(H4,13,14,15,17,18)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	165	n/a	n/a	n/a	n/a	7.4	22
TargeGen Inc.					Assay Description The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...				Proc Natl Acad Sci U S A 103: 19866-71 (2006) Article DOI: 10.1073/pnas.0606956103 BindingDB Entry DOI: 10.7270/Q2J101GM
					More data for this Ligand-Target Pair