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SMILES: COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)\C=C\c1ccc(cc1)C#N

InChI Key: InChIKey=MLZCSSCIFZEIRS-HVHJFMEUSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 251327   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cobra venom factor/Complement factor B/Complement factor D


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)		BDBM251327
PNG
(US9452990, 7)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)\C=C\c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C25H25FN6O3/c1-15-14-31(20(33)9-8-16-4-6-17(13-27)7-5-16)10-11-32(15)25-29-22-18(24(28)30-25)12-19(34-2)23(35-3)21(22)26/h4-9,12,15H,10-11,14H2,1-3H3,(H2,28,29,30)/b9-8+/t15-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/a7.425



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...

US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair