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BDBM251378 US9452990, 58

SMILES: COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)C[C@@H](N)c1ccc(cc1)C#N

InChI Key: InChIKey=OTWJXDKBABVVIK-FDZZJVBBNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 251378   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251378
PNG
(US9452990, 58)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)C[C@@H](N)c1ccc(cc1)C#N
Show InChI InChI=1/C25H28FN7O3/c1-14-13-32(20(34)11-18(28)16-6-4-15(12-27)5-7-16)8-9-33(14)25-30-22-17(24(29)31-25)10-19(35-2)23(36-3)21(22)26/h4-7,10,14,18H,8-9,11,13,28H2,1-3H3,(H2,29,30,31)/t14-,18+/s2
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
US Patent
n/an/a 9n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


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Ligand-Target Pair