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BDBM251401 US9452990, 83

SMILES: COc1cc2nc(nc(N)c2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(F)cc1

InChI Key: InChIKey=CBMMOFVXJUEGPI-OAHLLOKOSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 251401   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cobra venom factor/Complement factor B/Complement factor D


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)		BDBM251401
PNG
(US9452990, 83)
Show SMILES COc1cc2nc(nc(N)c2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H26F2N6O3/c1-33-17-12-16-19(20(25)21(17)34-2)22(27)29-23(28-16)31-9-7-30(8-10-31)18(32)11-15(26)13-3-5-14(24)6-4-13/h3-6,12,15H,7-11,26H2,1-2H3,(H2,27,28,29)/t15-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/a7.425



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...

US Patent US9452990 (2016)


BindingDB Entry DOI: 10.7270/Q2H130Z9
More data for this
Ligand-Target Pair