null

SMILES: CNc1nc2ccccc2n1-c1nc2N3CCOCC3COc2c(n1)C(C)(C)O

InChI Key: InChIKey=OGEXLHLASSEQGO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 251616   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM251616 (US9453031, 39) Show SMILES CNc1nc2ccccc2n1-c1nc2N3CCOCC3COc2c(n1)C(C)(C)O Show InChI InChI=1S/C20H24N6O3/c1-20(2,27)16-15-17(25-8-9-28-10-12(25)11-29-15)24-19(23-16)26-14-7-5-4-6-13(14)22-18(26)21-3/h4-7,12,27H,8-11H2,1-3H3,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.17E+3	n/a	n/a	n/a	n/a	7.5	25
Fundación Centro Nacional de Investigaciones Oncológicas Carlos III US Patent					Assay Description The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#33-016), which is a homogeneous assay to me...				US Patent US9453031 (2016) BindingDB Entry DOI: 10.7270/Q27H1HH8
					More data for this Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit (Homo sapiens (Human))	BDBM251616 (US9453031, 39) Show SMILES CNc1nc2ccccc2n1-c1nc2N3CCOCC3COc2c(n1)C(C)(C)O Show InChI InChI=1S/C20H24N6O3/c1-20(2,27)16-15-17(25-8-9-28-10-12(25)11-29-15)24-19(23-16)26-14-7-5-4-6-13(14)22-18(26)21-3/h4-7,12,27H,8-11H2,1-3H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.18E+3	n/a	n/a	n/a	n/a	7.5	37
Fundación Centro Nacional de Investigaciones Oncológicas Carlos III US Patent					Assay Description The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#90-0083), which is a homogeneous assay to m...				US Patent US9453031 (2016) BindingDB Entry DOI: 10.7270/Q27H1HH8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR [1360-2549] (Homo sapiens (Human))	BDBM251616 (US9453031, 39) Show SMILES CNc1nc2ccccc2n1-c1nc2N3CCOCC3COc2c(n1)C(C)(C)O Show InChI InChI=1S/C20H24N6O3/c1-20(2,27)16-15-17(25-8-9-28-10-12(25)11-29-15)24-19(23-16)26-14-7-5-4-6-13(14)22-18(26)21-3/h4-7,12,27H,8-11H2,1-3H3,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.24E+3	n/a	n/a	n/a	n/a	7.5	25
Fundación Centro Nacional de Investigaciones Oncológicas Carlos III US Patent					Assay Description The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...				US Patent US9453031 (2016) BindingDB Entry DOI: 10.7270/Q27H1HH8
					More data for this Ligand-Target Pair