BDBM251652 US9453031, 103
SMILES: Cc1cc2c(cccc2[nH]1)-c1nc2N3CCOC[C@H]3COc2c(n1)C(C)(C)S(C)(=O)=O
InChI Key:
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM251652 (US9453031, 103) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Fundación Centro Nacional de Investigaciones Oncológicas Carlos III US Patent | Assay Description The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#33-016), which is a homogeneous assay to me... | US Patent US9453031 (2016) BindingDB Entry DOI: 10.7270/Q27H1HH8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-dependent protein kinase catalytic subunit (Homo sapiens (Human)) | BDBM251652 (US9453031, 103) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Fundación Centro Nacional de Investigaciones Oncológicas Carlos III US Patent | Assay Description The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#90-0083), which is a homogeneous assay to m... | US Patent US9453031 (2016) BindingDB Entry DOI: 10.7270/Q27H1HH8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase mTOR [1360-2549] (Homo sapiens (Human)) | BDBM251652 (US9453031, 103) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 58 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Fundación Centro Nacional de Investigaciones Oncológicas Carlos III US Patent | Assay Description The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ... | US Patent US9453031 (2016) BindingDB Entry DOI: 10.7270/Q27H1HH8 | |||||||||||
More data for this Ligand-Target Pair |