null
SMILES: Cc1ccc(O)cc1Nc1ccnc2ccc(cc12)-c1cccnc1
InChI Key: InChIKey=BYVUAJDYENVNAV-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM25195 (4-methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}p...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline | Assay Description The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in... | Bioorg Med Chem Lett 17: 5886-93 (2007) Article DOI: 10.1016/j.bmcl.2007.07.104 BindingDB Entry DOI: 10.7270/Q2H1309S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM25195 (4-methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of VEGFR2(unknown origin) | J Med Chem 59: 4867-80 (2016) BindingDB Entry DOI: 10.7270/Q2G162SQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM25195 (4-methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 3.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of p38alpha (unknown origin) | J Med Chem 59: 4867-80 (2016) BindingDB Entry DOI: 10.7270/Q2G162SQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM25195 (4-methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}p...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Competitive inhibition of full length FLAG-His-tagged RIP2K (unknown origin) expressed in baculovirus expression system preincubated for 10 mins foll... | J Med Chem 59: 4867-80 (2016) BindingDB Entry DOI: 10.7270/Q2G162SQ | |||||||||||
More data for this Ligand-Target Pair |