Found 6 hits for monomerid = 25284 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Geranylgeranyl Diphosphate Synthase (GGPPS)
(Homo sapiens (Human)) | BDBM25284
((1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phen...)Show SMILES OC(Cc1cccc(c1)-c1cccc(NS(=O)(=O)c2ccc3ccccc3c2)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C24H23NO9P2S/c26-24(35(27,28)29,36(30,31)32)16-17-5-3-8-19(13-17)20-9-4-10-22(14-20)25-37(33,34)23-12-11-18-6-1-2-7-21(18)15-23/h1-15,25-26H,16H2,(H2,27,28,29)(H2,30,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry
Curated by ChEMBL
| Assay Description Binding affinity to human GGPPS |
Proc Natl Acad Sci USA 104: 10022-7 (2007)
Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F |
More data for this Ligand-Target Pair | |
Geranylgeranyl diphosphate synthase (GGPPS)
(Saccharomyces cerevisiae (Yeast)) | BDBM25284
((1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phen...)Show SMILES OC(Cc1cccc(c1)-c1cccc(NS(=O)(=O)c2ccc3ccccc3c2)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C24H23NO9P2S/c26-24(35(27,28)29,36(30,31)32)16-17-5-3-8-19(13-17)20-9-4-10-22(14-20)25-37(33,34)23-12-11-18-6-1-2-7-21(18)15-23/h1-15,25-26H,16H2,(H2,27,28,29)(H2,30,31,32) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry
Curated by ChEMBL
| Assay Description Binding affinity to Saccharomyces cerevisiae GGPPS |
Proc Natl Acad Sci USA 104: 10022-7 (2007)
Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Geranylgeranyl Diphosphate Synthase (GGPPS)
(Homo sapiens (Human)) | BDBM25284
((1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phen...)Show SMILES OC(Cc1cccc(c1)-c1cccc(NS(=O)(=O)c2ccc3ccccc3c2)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C24H23NO9P2S/c26-24(35(27,28)29,36(30,31)32)16-17-5-3-8-19(13-17)20-9-4-10-22(14-20)25-37(33,34)23-12-11-18-6-1-2-7-21(18)15-23/h1-15,25-26H,16H2,(H2,27,28,29)(H2,30,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry
Curated by ChEMBL
| Assay Description Inhibition of human GGPPS |
Proc Natl Acad Sci USA 104: 10022-7 (2007)
Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F |
More data for this Ligand-Target Pair | |
cis-Decaprenyl diphosphate synthase (cis-DPPS)
(Mycobacterium tuberculosis H37Rv) | BDBM25284
((1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phen...)Show SMILES OC(Cc1cccc(c1)-c1cccc(NS(=O)(=O)c2ccc3ccccc3c2)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C24H23NO9P2S/c26-24(35(27,28)29,36(30,31)32)16-17-5-3-8-19(13-17)20-9-4-10-22(14-20)25-37(33,34)23-12-11-18-6-1-2-7-21(18)15-23/h1-15,25-26H,16H2,(H2,27,28,29)(H2,30,31,32) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 8.20E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of California San Diego
| Assay Description We screened an in-house library of 53 compounds using trans-FPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by ... |
Chem Biol Drug Des 85: 756-69 (2015)
Article DOI: 10.1111/cbdd.12463 BindingDB Entry DOI: 10.7270/Q2ZG6QZN |
More data for this Ligand-Target Pair | |
Geranylgeranyl Diphosphate Synthase (GGPPS)
(Homo sapiens (Human)) | BDBM25284
((1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phen...)Show SMILES OC(Cc1cccc(c1)-c1cccc(NS(=O)(=O)c2ccc3ccccc3c2)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C24H23NO9P2S/c26-24(35(27,28)29,36(30,31)32)16-17-5-3-8-19(13-17)20-9-4-10-22(14-20)25-37(33,34)23-12-11-18-6-1-2-7-21(18)15-23/h1-15,25-26H,16H2,(H2,27,28,29)(H2,30,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 2.69E+3 | n/a | n/a | n/a | n/a | 7.0 | 37 |
National Taiwan University
| Assay Description The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co... |
J Med Chem 51: 5594-607 (2008)
Article DOI: 10.1021/jm800325y BindingDB Entry DOI: 10.7270/Q2028PVT |
More data for this Ligand-Target Pair | |
Geranylgeranyl diphosphate synthase (GGPPS)
(Saccharomyces cerevisiae (Yeast)) | BDBM25284
((1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phen...)Show SMILES OC(Cc1cccc(c1)-c1cccc(NS(=O)(=O)c2ccc3ccccc3c2)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C24H23NO9P2S/c26-24(35(27,28)29,36(30,31)32)16-17-5-3-8-19(13-17)20-9-4-10-22(14-20)25-37(33,34)23-12-11-18-6-1-2-7-21(18)15-23/h1-15,25-26H,16H2,(H2,27,28,29)(H2,30,31,32) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry
Curated by ChEMBL
| Assay Description Inhibition of Saccharomyces cerevisiae GGPPS |
Proc Natl Acad Sci USA 104: 10022-7 (2007)
Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F |
More data for this Ligand-Target Pair | 3D Structure (crystal) |