Found 6 hits for monomerid = 25297 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Geranylgeranyl diphosphate synthase (GGPPS)
(Saccharomyces cerevisiae (Yeast)) | BDBM25297
(1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoeth...)Show SMILES OC(C[n+]1cccc(c1)-c1cccc(c1)-c1ccccc1)(P(O)(O)=O)P(O)([O-])=O Show InChI InChI=1S/C19H19NO7P2/c21-19(28(22,23)24,29(25,26)27)14-20-11-5-10-18(13-20)17-9-4-8-16(12-17)15-6-2-1-3-7-15/h1-13,21H,14H2,(H3-,22,23,24,25,26,27) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry
Curated by ChEMBL
| Assay Description Binding affinity to Saccharomyces cerevisiae GGPPS |
Proc Natl Acad Sci USA 104: 10022-7 (2007)
Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F |
More data for this Ligand-Target Pair | |
Geranylgeranyl Diphosphate Synthase (GGPPS)
(Homo sapiens (Human)) | BDBM25297
(1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoeth...)Show SMILES OC(C[n+]1cccc(c1)-c1cccc(c1)-c1ccccc1)(P(O)(O)=O)P(O)([O-])=O Show InChI InChI=1S/C19H19NO7P2/c21-19(28(22,23)24,29(25,26)27)14-20-11-5-10-18(13-20)17-9-4-8-16(12-17)15-6-2-1-3-7-15/h1-13,21H,14H2,(H3-,22,23,24,25,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry
Curated by ChEMBL
| Assay Description Binding affinity to human GGPPS |
Proc Natl Acad Sci USA 104: 10022-7 (2007)
Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F |
More data for this Ligand-Target Pair | |
Farnesyl pyrophosphate synthase
(Plasmodium falciparum (isolate 3D7)) | BDBM25297
(1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoeth...)Show SMILES OC(C[n+]1cccc(c1)-c1cccc(c1)-c1ccccc1)(P(O)(O)=O)P(O)([O-])=O Show InChI InChI=1S/C19H19NO7P2/c21-19(28(22,23)24,29(25,26)27)14-20-11-5-10-18(13-20)17-9-4-8-16(12-17)15-6-2-1-3-7-15/h1-13,21H,14H2,(H3-,22,23,24,25,26,27) | PDB
KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 950 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Urbana-Champaign
Curated by ChEMBL
| Assay Description Binding affinity towards Farnesyl diphosphate synthase from leishmania major |
J Med Chem 48: 2957-63 (2005)
Article DOI: 10.1021/jm040209d BindingDB Entry DOI: 10.7270/Q2Z89D7K |
More data for this Ligand-Target Pair | |
Geranylgeranyl Diphosphate Synthase (GGPPS)
(Homo sapiens (Human)) | BDBM25297
(1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoeth...)Show SMILES OC(C[n+]1cccc(c1)-c1cccc(c1)-c1ccccc1)(P(O)(O)=O)P(O)([O-])=O Show InChI InChI=1S/C19H19NO7P2/c21-19(28(22,23)24,29(25,26)27)14-20-11-5-10-18(13-20)17-9-4-8-16(12-17)15-6-2-1-3-7-15/h1-13,21H,14H2,(H3-,22,23,24,25,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry
Curated by ChEMBL
| Assay Description Inhibition of human GGPPS |
Proc Natl Acad Sci USA 104: 10022-7 (2007)
Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F |
More data for this Ligand-Target Pair | |
Geranylgeranyl Diphosphate Synthase (GGPPS)
(Homo sapiens (Human)) | BDBM25297
(1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoeth...)Show SMILES OC(C[n+]1cccc(c1)-c1cccc(c1)-c1ccccc1)(P(O)(O)=O)P(O)([O-])=O Show InChI InChI=1S/C19H19NO7P2/c21-19(28(22,23)24,29(25,26)27)14-20-11-5-10-18(13-20)17-9-4-8-16(12-17)15-6-2-1-3-7-15/h1-13,21H,14H2,(H3-,22,23,24,25,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.12E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Taiwan University
| Assay Description The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co... |
J Med Chem 51: 5594-607 (2008)
Article DOI: 10.1021/jm800325y BindingDB Entry DOI: 10.7270/Q2028PVT |
More data for this Ligand-Target Pair | |
Geranylgeranyl diphosphate synthase (GGPPS)
(Saccharomyces cerevisiae (Yeast)) | BDBM25297
(1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoeth...)Show SMILES OC(C[n+]1cccc(c1)-c1cccc(c1)-c1ccccc1)(P(O)(O)=O)P(O)([O-])=O Show InChI InChI=1S/C19H19NO7P2/c21-19(28(22,23)24,29(25,26)27)14-20-11-5-10-18(13-20)17-9-4-8-16(12-17)15-6-2-1-3-7-15/h1-13,21H,14H2,(H3-,22,23,24,25,26,27) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Biological Chemistry
Curated by ChEMBL
| Assay Description Inhibition of Saccharomyces cerevisiae GGPPS |
Proc Natl Acad Sci USA 104: 10022-7 (2007)
Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F |
More data for this Ligand-Target Pair | |