BDBM253928 US10189849, Compound 27::US10927120, Compound 27::US9464092, T::US9527857, T::US9957276, Compound 27
SMILES: CN1CCN(CC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)nc1
InChI Key: InChIKey=PDGKHKMBHVFCMG-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
G1 Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK6/CycD3 CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.... | US Patent US9464092 (2016) BindingDB Entry DOI: 10.7270/Q28C9V5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK2/CycE (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 5.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GI Therapeutics, Inc. US Patent | Assay Description For the measurement of CDK2/cyclinE activity, enzyme (0.22 nM) was incubated with 100 mM ATP and the phosphoacceptor substrate peptide (1 mM) for one... | US Patent US10927120 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Dependent Kinase 2 (CDK2) (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 1.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
G1 Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK6/CycD3 CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.... | US Patent US9464092 (2016) BindingDB Entry DOI: 10.7270/Q28C9V5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 0.821 | n/a | n/a | n/a | n/a | n/a | n/a |
G1 Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK6/CycD3 CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.... | US Patent US9464092 (2016) BindingDB Entry DOI: 10.7270/Q28C9V5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK2/CycE (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 1.66 | n/a | n/a | n/a | n/a | n/a | n/a |
G1 Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK6/CycD3 CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.... | US Patent US9464092 (2016) BindingDB Entry DOI: 10.7270/Q28C9V5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Dependent Kinase 2 (CDK2) (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 1.67 | n/a | n/a | n/a | n/a | n/a | n/a |
G1 Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK6/CycD3 CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.... | US Patent US9464092 (2016) BindingDB Entry DOI: 10.7270/Q28C9V5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK6/CycD3 (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 5.64 | n/a | n/a | n/a | n/a | n/a | n/a |
G1 Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK6/CycD3 CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.... | US Patent US9464092 (2016) BindingDB Entry DOI: 10.7270/Q28C9V5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK2/CycE (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 1.66E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GI Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ... | US Patent US9527857 (2016) BindingDB Entry DOI: 10.7270/Q2CN72V8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK2/Cyclin A1 (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 1.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GI Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ... | US Patent US9527857 (2016) BindingDB Entry DOI: 10.7270/Q2CN72V8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
GI Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ... | US Patent US9527857 (2016) BindingDB Entry DOI: 10.7270/Q2CN72V8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 0.821 | n/a | n/a | n/a | n/a | n/a | n/a |
GI Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ... | US Patent US9527857 (2016) BindingDB Entry DOI: 10.7270/Q2CN72V8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK2/CycE (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 1.66E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GI Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ... | US Patent US9527857 (2016) BindingDB Entry DOI: 10.7270/Q2MK6B2C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
GI Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ... | US Patent US9527857 (2016) BindingDB Entry DOI: 10.7270/Q2MK6B2C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Dependent Kinase 2 (CDK2) (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 1.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GI Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ... | US Patent US9527857 (2016) BindingDB Entry DOI: 10.7270/Q2MK6B2C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK2/CycE (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 5.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
G1 Therapeutics, Inc. US Patent | Assay Description Kinase enzymatic reactions were performed in 384-well microplates using a 12-channel Caliper LabChip instrument as a detection device. The enzymatic ... | US Patent US10189849 (2019) BindingDB Entry DOI: 10.7270/Q2WQ05V6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK2/CycE (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 5.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical | Assay Description Kinase enzymatic reactions were performed in 384-well microplates using a 12-channel Caliper LabChip instrument as a detection device. The enzymatic ... | J Med Chem 52: 1081-99 (2009) BindingDB Entry DOI: 10.7270/Q26975WZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK6/CycD3 (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Inhibition of human CDK6/cyclin D3 | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126637 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Inhibition of human CDK4/cyclinD1 | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126637 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Inhibition of human CDK4/cyclinD1 | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126637 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK2/CycE (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Inhibition of human CDK2/cyclin E | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126637 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK2/CycE (Homo sapiens (Human)) | BDBM253928 (US10189849, Compound 27 | US10927120, Compound 27 ...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 1.66E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
G1 Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK6/CycD3 CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.... | US Patent US9464092 (2016) BindingDB Entry DOI: 10.7270/Q28C9V5W | |||||||||||
More data for this Ligand-Target Pair |