BDBM254106 US9481677, 34.24

SMILES: Fc1cccnc1NS(=O)(=O)c1cc(F)c(Oc2ccc(Cl)cc2-c2cccc3nccn23)cc1F

InChI Key: InChIKey=ACTJBFRGINIVLF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 254106   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM254106 (US9481677, 34.24) Show SMILES Fc1cccnc1NS(=O)(=O)c1cc(F)c(Oc2ccc(Cl)cc2-c2cccc3nccn23)cc1F Show InChI InChI=1S/C24H14ClF3N4O3S/c25-14-6-7-20(15(11-14)19-4-1-5-23-29-9-10-32(19)23)35-21-12-18(28)22(13-17(21)27)36(33,34)31-24-16(26)3-2-8-30-24/h1-13H,(H,30,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	23.2	n/a	n/a	n/a	n/a	n/a	n/a
XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...				US Patent US9481677 (2016) BindingDB Entry DOI: 10.7270/Q20V8BQT
					More data for this Ligand-Target Pair