BDBM254553 US9469597, 12::US9670136, 12 4-(((trans)-2-(6-(3-(trifluoromethyl)phenyl)pyridin-3-yl)cyclopropyl)amino)cyclohexanecarboxamide
SMILES: NC(=O)C1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(nc1)-c1cccc(c1)C(F)(F)F
InChI Key: InChIKey=WVVHNLMQBRBRGZ-DTYDVHMXSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lysine-specific histone demethylase 1A (Homo sapiens (Human)) | BDBM254553 (US9469597, 12 | US9670136, 12 4-(((trans)-2-(6-(3-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 50 | -9.95 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
ORYZON GENOMICS S.A. US Patent | Assay Description Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ... | US Patent US9670136 (2017) BindingDB Entry DOI: 10.7270/Q2PN93SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GST-Lysine Specific Demethylase-1 (LSD1) (Homo sapiens (Human)) | BDBM254553 (US9469597, 12 | US9670136, 12 4-(((trans)-2-(6-(3-...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 50 | -10.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Oryzon Genomics S.A. US Patent | Assay Description The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ... | US Patent US9469597 (2016) BindingDB Entry DOI: 10.7270/Q2ZW1JVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase [flavin-containing] B (Homo sapiens (Human)) | BDBM254553 (US9469597, 12 | US9670136, 12 4-(((trans)-2-(6-(3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2.00E+4 | -6.66 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
Oryzon Genomics S.A. US Patent | Assay Description In order to monitor MAO enzymatic activities and/or their inhibition rate by inhibitor(s) of interest, a fluorescence-based (inhibitor)-screening ass... | US Patent US9469597 (2016) BindingDB Entry DOI: 10.7270/Q2ZW1JVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase (flavin-containing) A (Homo sapiens (Human)) | BDBM254553 (US9469597, 12 | US9670136, 12 4-(((trans)-2-(6-(3-...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2.00E+4 | -6.66 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
Oryzon Genomics S.A. US Patent | Assay Description In order to monitor MAO enzymatic activities and/or their inhibition rate by inhibitor(s) of interest, a fluorescence-based (inhibitor)-screening ass... | US Patent US9469597 (2016) BindingDB Entry DOI: 10.7270/Q2ZW1JVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase [flavin-containing] B (Homo sapiens (Human)) | BDBM254553 (US9469597, 12 | US9670136, 12 4-(((trans)-2-(6-(3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
ORYZON GENOMICS S.A. US Patent | Assay Description Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ... | US Patent US9670136 (2017) BindingDB Entry DOI: 10.7270/Q2PN93SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase (flavin-containing) A (Homo sapiens (Human)) | BDBM254553 (US9469597, 12 | US9670136, 12 4-(((trans)-2-(6-(3-...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
ORYZON GENOMICS S.A. US Patent | Assay Description Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ... | US Patent US9670136 (2017) BindingDB Entry DOI: 10.7270/Q2PN93SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase [flavin-containing] B (Homo sapiens (Human)) | BDBM254553 (US9469597, 12 | US9670136, 12 4-(((trans)-2-(6-(3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ORYZON GENOMICS S.A. US Patent | Assay Description Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ... | US Patent US9670136 (2017) BindingDB Entry DOI: 10.7270/Q2PN93SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase (flavin-containing) A (Homo sapiens (Human)) | BDBM254553 (US9469597, 12 | US9670136, 12 4-(((trans)-2-(6-(3-...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.52E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ORYZON GENOMICS S.A. US Patent | Assay Description Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ... | US Patent US9670136 (2017) BindingDB Entry DOI: 10.7270/Q2PN93SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific histone demethylase 1A (Homo sapiens (Human)) | BDBM254553 (US9469597, 12 | US9670136, 12 4-(((trans)-2-(6-(3-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 91 | n/a | n/a | n/a | n/a | 7.4 | 25 |
ORYZON GENOMICS S.A. US Patent | Assay Description Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ... | US Patent US9670136 (2017) BindingDB Entry DOI: 10.7270/Q2PN93SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase [flavin-containing] B (Homo sapiens (Human)) | BDBM254553 (US9469597, 12 | US9670136, 12 4-(((trans)-2-(6-(3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Oryzon Genomics S.A. US Patent | Assay Description In order to monitor MAO enzymatic activities and/or their inhibition rate by inhibitor(s) of interest, a fluorescence-based (inhibitor)-screening ass... | US Patent US9469597 (2016) BindingDB Entry DOI: 10.7270/Q2ZW1JVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase (flavin-containing) A (Homo sapiens (Human)) | BDBM254553 (US9469597, 12 | US9670136, 12 4-(((trans)-2-(6-(3-...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.52E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Oryzon Genomics S.A. US Patent | Assay Description In order to monitor MAO enzymatic activities and/or their inhibition rate by inhibitor(s) of interest, a fluorescence-based (inhibitor)-screening ass... | US Patent US9469597 (2016) BindingDB Entry DOI: 10.7270/Q2ZW1JVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GST-Lysine Specific Demethylase-1 (LSD1) (Homo sapiens (Human)) | BDBM254553 (US9469597, 12 | US9670136, 12 4-(((trans)-2-(6-(3-...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 91 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Oryzon Genomics S.A. US Patent | Assay Description The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ... | US Patent US9469597 (2016) BindingDB Entry DOI: 10.7270/Q2ZW1JVG | |||||||||||
More data for this Ligand-Target Pair |