BDBM254932 US9499542, 15::US9675594, 15
SMILES: Cc1cc(ccc1CN1CCOCC1)-c1cc(Nc2ccn(C)n2)nc2[nH]cc(C#N)c12
InChI Key: InChIKey=ANIYDVYTJUHGSI-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S (Homo sapiens (Human)) | BDBM254932 (US9499542, 15 | US9675594, 15) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 8.5 | 30 |
H. Lundbeck A/S; Vernalis (R&D) Ltd. US Patent | Assay Description LRRK2 kinase activity is measured using a LanthaScreen kinase activity assay available from Invitrogen (Life Technologies Corporation). The assay is ... | US Patent US9499542 (2016) BindingDB Entry DOI: 10.7270/Q22N516S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human)) | BDBM254932 (US9499542, 15 | US9675594, 15) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
NMMLSC US Patent | Assay Description In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th... | US Patent US9675594 (2017) BindingDB Entry DOI: 10.7270/Q2ZC8110 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S) (Homo sapiens (Human)) | BDBM254932 (US9499542, 15 | US9675594, 15) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
NMMLSC US Patent | Assay Description In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th... | US Patent US9675594 (2017) BindingDB Entry DOI: 10.7270/Q2ZC8110 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human)) | BDBM254932 (US9499542, 15 | US9675594, 15) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | 8.5 | 30 |
H. Lundbeck A/S; Vernalis (R&D) Ltd. US Patent | Assay Description LRRK2 kinase activity is measured using a LanthaScreen kinase activity assay available from Invitrogen (Life Technologies Corporation). The assay is ... | US Patent US9499542 (2016) BindingDB Entry DOI: 10.7270/Q22N516S | |||||||||||
More data for this Ligand-Target Pair |