BDBM255003 US9475813, 8
SMILES: OC[C@H]1CC[C@@H](CC1)N1CN(CC#N)C(=O)c2cnc3[nH]ccc3c12
InChI Key:
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM255003 (US9475813, 8) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Nissan Chemical Industries, Ltd. US Patent | Assay Description The inhibitory activity of the compounds of the present invention against JAK was measured.The respective enzymes (JAK1, JAK2, JAK3 and Tyk2) were pu... | US Patent US9475813 (2016) BindingDB Entry DOI: 10.7270/Q2PC31BN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM255003 (US9475813, 8) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Nissan Chemical Industries, Ltd. US Patent | Assay Description The inhibitory activity of the compounds of the present invention against JAK was measured.The respective enzymes (JAK1, JAK2, JAK3 and Tyk2) were pu... | US Patent US9475813 (2016) BindingDB Entry DOI: 10.7270/Q2PC31BN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM255003 (US9475813, 8) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Nissan Chemical Industries, Ltd. US Patent | Assay Description The inhibitory activity of the compounds of the present invention against JAK was measured.The respective enzymes (JAK1, JAK2, JAK3 and Tyk2) were pu... | US Patent US9475813 (2016) BindingDB Entry DOI: 10.7270/Q2PC31BN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM255003 (US9475813, 8) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Nissan Chemical Industries, Ltd. US Patent | Assay Description The inhibitory activity of the compounds of the present invention against JAK was measured.The respective enzymes (JAK1, JAK2, JAK3 and Tyk2) were pu... | US Patent US9475813 (2016) BindingDB Entry DOI: 10.7270/Q2PC31BN | |||||||||||
More data for this Ligand-Target Pair |