BDBM25510 2-amino-pyrazolopyridine, 16::3-methyl-N-[(1S)-1-phenylethyl]-1-[3-(propan-2-yl)phenyl]-1H-pyrazolo[4,3-c]pyridin-6-amine

SMILES: CC(C)c1cccc(c1)-n1nc(C)c2cnc(N[C@@H](C)c3ccccc3)cc12

InChI Key: InChIKey=KJXJPUPIAYZGOR-KRWDZBQOSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25510   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM25510 (2-amino-pyrazolopyridine, 16 | 3-methyl-N-[(1S)-1-...) Show SMILES CC(C)c1cccc(c1)-n1nc(C)c2cnc(N[C@@H](C)c3ccccc3)cc12 |r| Show InChI InChI=1S/C24H26N4/c1-16(2)20-11-8-12-21(13-20)28-23-14-24(25-15-22(23)18(4)27-28)26-17(3)19-9-6-5-7-10-19/h5-17H,1-4H3,(H,25,26)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.48E+3	n/a	n/a	n/a	n/a	7.2	30
Sunesis Pharmaceuticals					Assay Description An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...				Bioorg Med Chem Lett 18: 5648-52 (2008) Article DOI: 10.1016/j.bmcl.2008.08.095 BindingDB Entry DOI: 10.7270/Q29C6VRP
					More data for this Ligand-Target Pair