BDBM25519 2-amino-pyrazolopyridine, 30::3-[3-chloro-5-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]-N-(2-hydroxyethyl)propanamide

SMILES: C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(CCC(=O)NCCO)c1)c1ccccc1

InChI Key: InChIKey=VDGVHPMRIRMMNM-KRWDZBQOSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25519   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM25519 (2-amino-pyrazolopyridine, 30 | 3-[3-chloro-5-(3-me...) Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(CCC(=O)NCCO)c1)c1ccccc1 |r| Show InChI InChI=1S/C26H28ClN5O2/c1-17(20-6-4-3-5-7-20)30-25-15-24-23(16-29-25)18(2)31-32(24)22-13-19(12-21(27)14-22)8-9-26(34)28-10-11-33/h3-7,12-17,33H,8-11H2,1-2H3,(H,28,34)(H,29,30)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	7.2	30
Sunesis Pharmaceuticals					Assay Description An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...				Bioorg Med Chem Lett 18: 5648-52 (2008) Article DOI: 10.1016/j.bmcl.2008.08.095 BindingDB Entry DOI: 10.7270/Q29C6VRP
					More data for this Ligand-Target Pair