null

SMILES: Fc1cnc(Nc2ccc3cn[nH]c3c2)nc1Nc1ccc2OCCOc2c1

InChI Key: InChIKey=UFWSUWIWEXKNGP-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 255487   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255487 (US10828301, Compound R935190 | US9499493, R935190) Show SMILES Fc1cnc(Nc2ccc3cn[nH]c3c2)nc1Nc1ccc2OCCOc2c1 Show InChI InChI=1S/C19H15FN6O2/c20-14-10-21-19(24-12-2-1-11-9-22-26-15(11)7-12)25-18(14)23-13-3-4-16-17(8-13)28-6-5-27-16/h1-4,7-10H,5-6H2,(H,22,26)(H2,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46.5	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255487 (US10828301, Compound R935190 | US9499493, R935190) Show SMILES Fc1cnc(Nc2ccc3cn[nH]c3c2)nc1Nc1ccc2OCCOc2c1 Show InChI InChI=1S/C19H15FN6O2/c20-14-10-21-19(24-12-2-1-11-9-22-26-15(11)7-12)25-18(14)23-13-3-4-16-17(8-13)28-6-5-27-16/h1-4,7-10H,5-6H2,(H,22,26)(H2,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46.5	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair