BDBM255505 US10828301, Compound R926839::US9499493, R926839

SMILES: CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc(C)c(Cl)c3)n2)c1

InChI Key: InChIKey=BHYASVJYBYOTBO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 255505   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255505 (US10828301, Compound R926839 | US9499493, R926839) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc(C)c(Cl)c3)n2)c1 Show InChI InChI=1S/C20H19ClFN5O2/c1-12-6-7-14(9-16(12)21)25-19-17(22)10-24-20(27-19)26-13-4-3-5-15(8-13)29-11-18(28)23-2/h3-10H,11H2,1-2H3,(H,23,28)(H2,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255505 (US10828301, Compound R926839 | US9499493, R926839) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc(C)c(Cl)c3)n2)c1 Show InChI InChI=1S/C20H19ClFN5O2/c1-12-6-7-14(9-16(12)21)25-19-17(22)10-24-20(27-19)26-13-4-3-5-15(8-13)29-11-18(28)23-2/h3-10H,11H2,1-2H3,(H,23,28)(H2,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair