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SMILES: OCCCn1ncc2ccc(Nc3ncc(F)c(Nc4cccc(O)c4)n3)cc12

InChI Key: InChIKey=GBLOYDFOXLQLIP-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 255507   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255507 (US10828301, Compound R935293 | US9499493, R935293) Show SMILES OCCCn1ncc2ccc(Nc3ncc(F)c(Nc4cccc(O)c4)n3)cc12 Show InChI InChI=1S/C20H19FN6O2/c21-17-12-22-20(26-19(17)24-14-3-1-4-16(29)9-14)25-15-6-5-13-11-23-27(7-2-8-28)18(13)10-15/h1,3-6,9-12,28-29H,2,7-8H2,(H2,22,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46.5	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255507 (US10828301, Compound R935293 | US9499493, R935293) Show SMILES OCCCn1ncc2ccc(Nc3ncc(F)c(Nc4cccc(O)c4)n3)cc12 Show InChI InChI=1S/C20H19FN6O2/c21-17-12-22-20(26-19(17)24-14-3-1-4-16(29)9-14)25-15-6-5-13-11-23-27(7-2-8-28)18(13)10-15/h1,3-6,9-12,28-29H,2,7-8H2,(H2,22,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46.5	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair