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SMILES: OCCCn1ncc2cc(Nc3ncc(F)c(Nc4ccc5OCCOc5c4)n3)ccc12

InChI Key: InChIKey=DGIQLYMAFCCUGW-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 255508   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255508 (US10828301, Compound R935302 | US9499493, R935302) Show SMILES OCCCn1ncc2cc(Nc3ncc(F)c(Nc4ccc5OCCOc5c4)n3)ccc12 Show InChI InChI=1S/C22H21FN6O3/c23-17-13-24-22(27-15-2-4-18-14(10-15)12-25-29(18)6-1-7-30)28-21(17)26-16-3-5-19-20(11-16)32-9-8-31-19/h2-5,10-13,30H,1,6-9H2,(H2,24,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26.5	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255508 (US10828301, Compound R935302 | US9499493, R935302) Show SMILES OCCCn1ncc2cc(Nc3ncc(F)c(Nc4ccc5OCCOc5c4)n3)ccc12 Show InChI InChI=1S/C22H21FN6O3/c23-17-13-24-22(27-15-2-4-18-14(10-15)12-25-29(18)6-1-7-30)28-21(17)26-16-3-5-19-20(11-16)32-9-8-31-19/h2-5,10-13,30H,1,6-9H2,(H2,24,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26.5	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair