BDBM255513 US10828301, Compound R940338::US9499493, R940338
SMILES: Cn1ncc2cc(Nc3ncc(F)c(Nc4ccc5OC(C)(C)C(=O)Nc5c4)n3)ccc12
InChI Key: InChIKey=YJZNNCBZUHWOEH-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM255513 (US10828301, Compound R940338 | US9499493, R940338) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Rigel Pharmceuticals, Inc. US Patent | Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch... | US Patent US10828301 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM255513 (US10828301, Compound R940338 | US9499493, R940338) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 28 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Rigel Pharmaceuticals, Inc. US Patent | Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch... | US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ | |||||||||||
More data for this Ligand-Target Pair |