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SMILES: CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCC(=O)Nc4n3)n2)c1

InChI Key: InChIKey=JUIWNYKVNSJFNO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 255514   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255514 (US10828301, Compound R921304 | US9499493, R921304) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCC(=O)Nc4n3)n2)c1 Show InChI InChI=1S/C20H18FN7O4/c1-22-16(29)9-31-12-4-2-3-11(7-12)24-20-23-8-13(21)18(28-20)25-15-6-5-14-19(26-15)27-17(30)10-32-14/h2-8H,9-10H2,1H3,(H,22,29)(H3,23,24,25,26,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.8	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255514 (US10828301, Compound R921304 | US9499493, R921304) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCC(=O)Nc4n3)n2)c1 Show InChI InChI=1S/C20H18FN7O4/c1-22-16(29)9-31-12-4-2-3-11(7-12)24-20-23-8-13(21)18(28-20)25-15-6-5-14-19(26-15)27-17(30)10-32-14/h2-8H,9-10H2,1H3,(H,22,29)(H3,23,24,25,26,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.8	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair