BDBM25559 4-arylamino-3-pyridinecarbonitrile, 4q::5-(3,4-dimethoxyphenyl)-4-(1H-indol-6-ylamino)pyridine-3-carbonitrile::BMCL192461 Compound 1b::CHEMBL492252

SMILES: COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1ccc2cc[nH]c2c1

InChI Key: InChIKey=UXKAONQBOGJYCN-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 25559   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase C theta type (Homo sapiens (Human))	BDBM25559 (4-arylamino-3-pyridinecarbonitrile, 4q | 5-(3,4-di...) Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1ccc2cc[nH]c2c1 Show InChI InChI=1S/C22H18N4O2/c1-27-20-6-4-15(9-21(20)28-2)18-13-24-12-16(11-23)22(18)26-17-5-3-14-7-8-25-19(14)10-17/h3-10,12-13,25H,1-2H3,(H,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	7.2	22
Wyeth Research					Assay Description All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...				J Med Chem 51: 5958-63 (2008) Article DOI: 10.1021/jm800214a BindingDB Entry DOI: 10.7270/Q21V5C8K
					More data for this Ligand-Target Pair
Protein kinase C theta type (Homo sapiens (Human))	BDBM25559 (4-arylamino-3-pyridinecarbonitrile, 4q | 5-(3,4-di...) Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1ccc2cc[nH]c2c1 Show InChI InChI=1S/C22H18N4O2/c1-27-20-6-4-15(9-21(20)28-2)18-13-24-12-16(11-23)22(18)26-17-5-3-14-7-8-25-19(14)10-17/h3-10,12-13,25H,1-2H3,(H,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human PKCtheta by IMAP assay				Bioorg Med Chem Lett 19: 3623-6 (2009) Article DOI: 10.1016/j.bmcl.2009.04.126 BindingDB Entry DOI: 10.7270/Q29W0FD4
					More data for this Ligand-Target Pair
Protein kinase C theta type (Homo sapiens (Human))	BDBM25559 (4-arylamino-3-pyridinecarbonitrile, 4q | 5-(3,4-di...) Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1ccc2cc[nH]c2c1 Show InChI InChI=1S/C22H18N4O2/c1-27-20-6-4-15(9-21(20)28-2)18-13-24-12-16(11-23)22(18)26-17-5-3-14-7-8-25-19(14)10-17/h3-10,12-13,25H,1-2H3,(H,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	7.2	22
Wyeth Research					Assay Description All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...				Bioorg Med Chem Lett 19: 2461-3 (2009) Article DOI: 10.1016/j.bmcl.2009.03.053 BindingDB Entry DOI: 10.7270/Q21R6NVV
					More data for this Ligand-Target Pair