BDBM25620 (1Z)-5-[1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::pyrazole-based inhibitor, 2b

SMILES: Cn1ncc(c1-c1ccncc1)-c1ccc2C(CCc2c1)N=O

InChI Key: InChIKey=QUVQCDXLKWRQAX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25620   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM25620 ((1Z)-5-[1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl]...) Show SMILES Cn1ncc(c1-c1ccncc1)-c1ccc2C(CCc2c1)N=O Show InChI InChI=1S/C18H16N4O/c1-22-18(12-6-8-19-9-7-12)16(11-20-22)14-2-4-15-13(10-14)3-5-17(15)21-23/h2,4,6-11,17H,3,5H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.480	n/a	n/a	n/a	n/a	7.2	22
Array BioPharma					Assay Description Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...				Bioorg Med Chem Lett 18: 4692-5 (2008) Article DOI: 10.1016/j.bmcl.2008.07.002 BindingDB Entry DOI: 10.7270/Q2NK3CBJ
					More data for this Ligand-Target Pair