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SMILES: Cn1cc(c(n1)-c1ccncn1)-c1ccc2C(CCc2c1)N=O

InChI Key: InChIKey=QZKJNLHNTUOKIK-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25647   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase B-raf


(Homo sapiens (Human))		BDBM25647
PNG
((1Z)-5-[1-methyl-3-(pyrimidin-4-yl)-1H-pyrazol-4-y...)
Show SMILES Cn1cc(c(n1)-c1ccncn1)-c1ccc2C(CCc2c1)N=O
Show InChI InChI=1S/C17H15N5O/c1-22-9-14(17(20-22)16-6-7-18-10-19-16)12-2-4-13-11(8-12)3-5-15(13)21-23/h2,4,6-10,15H,3,5H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.10n/an/an/an/a7.222



Array BioPharma



Assay Description
Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...

Bioorg Med Chem Lett 18: 4692-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.002
BindingDB Entry DOI: 10.7270/Q2NK3CBJ
More data for this
Ligand-Target Pair