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SMILES: Cn1cc(c(n1)-c1ccncc1)-c1ccc2C(=O)NCc2c1

InChI Key: InChIKey=FLQRRMNRUINMJD-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 25654   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM25654 (5-[1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-...) Show SMILES Cn1cc(c(n1)-c1ccncc1)-c1ccc2C(=O)NCc2c1 Show InChI InChI=1S/C17H14N4O/c1-21-10-15(16(20-21)11-4-6-18-7-5-11)12-2-3-14-13(8-12)9-19-17(14)22/h2-8,10H,9H2,1H3,(H,19,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Curated by ChEMBL					Assay Description Inhibition of B-Raf				Bioorg Med Chem Lett 21: 3488-92 (2011) Article DOI: 10.1016/j.bmcl.2010.12.038 BindingDB Entry DOI: 10.7270/Q20R9PQ9
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM25654 (5-[1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-...) Show SMILES Cn1cc(c(n1)-c1ccncc1)-c1ccc2C(=O)NCc2c1 Show InChI InChI=1S/C17H14N4O/c1-21-10-15(16(20-21)11-4-6-18-7-5-11)12-2-3-14-13(8-12)9-19-17(14)22/h2-8,10H,9H2,1H3,(H,19,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	68.4	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma					Assay Description Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...				Bioorg Med Chem Lett 18: 4692-5 (2008) Article DOI: 10.1016/j.bmcl.2008.07.002 BindingDB Entry DOI: 10.7270/Q2NK3CBJ
					More data for this Ligand-Target Pair