BDBM25685 4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(2-methoxyethyl)-N-methylbenzamide::aminothiazole analogue, 29

SMILES: COCCN(C)C(=O)c1ccc(Nc2ncc(Br)s2)cc1

InChI Key: InChIKey=OHMRCNZQBXVUFZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25685   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM25685 (4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(2-methoxyet...) Show SMILES COCCN(C)C(=O)c1ccc(Nc2ncc(Br)s2)cc1 Show InChI InChI=1S/C14H16BrN3O2S/c1-18(7-8-20-2)13(19)10-3-5-11(6-4-10)17-14-16-9-12(15)21-14/h3-6,9H,7-8H2,1-2H3,(H,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	980	n/a	n/a	n/a	n/a	7.0	22
Novartis					Assay Description The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...				ACS Chem Biol 3: 180-92 (2008) Article DOI: 10.1021/cb700200w BindingDB Entry DOI: 10.7270/Q2HX1B03
					More data for this Ligand-Target Pair