BDBM25697 3-[(5-bromo-1,3-thiazol-2-yl)amino]benzoic acid::aminothiazole analogue, 41

SMILES: OC(=O)c1cccc(Nc2ncc(Br)s2)c1

InChI Key: InChIKey=KPIDOMYRAKPVIB-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25697   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM25697 (3-[(5-bromo-1,3-thiazol-2-yl)amino]benzoic acid | ...) Show SMILES OC(=O)c1cccc(Nc2ncc(Br)s2)c1 Show InChI InChI=1S/C10H7BrN2O2S/c11-8-5-12-10(16-8)13-7-3-1-2-6(4-7)9(14)15/h1-5H,(H,12,13)(H,14,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
Novartis					Assay Description The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...				ACS Chem Biol 3: 180-92 (2008) Article DOI: 10.1021/cb700200w BindingDB Entry DOI: 10.7270/Q2HX1B03
					More data for this Ligand-Target Pair