BDBM25807 4,4 -Dihydroxybenzophenone::4-[(4-hydroxyphenyl)carbonyl]phenol::Bis(p-hydroxy)benzophenone::Compound 0627-0373 (DHBP)::US9688816, N
SMILES: Oc1ccc(cc1)C(=O)c1ccc(O)cc1
InChI Key: InChIKey=RXNYJUSEXLAVNQ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Lanosterol 14-alpha demethylase (Mycobacterium tuberculosis (strain CDC 1551 / Oshk...) | BDBM25807 (4,4 -Dihydroxybenzophenone | 4-[(4-hydroxyphenyl)c...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | n/a | n/a | n/a | 2.80E+4 | n/a | n/a | n/a | 7.5 | 37 |
University of California at San Francisco | Assay Description The assay was developed based on the optical spectral property of P450 enzyme to elicit both type I and type II spectral changes (350 nm through 450 ... | Antimicrob Agents Chemother 51: 3915-23 (2007) Article DOI: 10.1128/AAC.00311-07 BindingDB Entry DOI: 10.7270/Q20V8B3R | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Estradiol receptor beta (ERβ) (Homo sapiens (Human)) | BDBM25807 (4,4 -Dihydroxybenzophenone | 4-[(4-hydroxyphenyl)c...) | PDB GoogleScholar AffyNet | Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SABIC GLOBAL TECHNOLOGIES B.V. US Patent | Assay Description Competitive binding assays were performed by incubating rhER alpha (α) and beta 1 (β1) receptors with 10 nM [3H]estradiol (the radio ligand... | US Patent US9688816 (2017) BindingDB Entry DOI: 10.7270/Q2WD3XR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor (Homo sapiens (Human)) | BDBM25807 (4,4 -Dihydroxybenzophenone | 4-[(4-hydroxyphenyl)c...) | PDB GoogleScholar AffyNet | Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 3.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SABIC GLOBAL TECHNOLOGIES B.V. US Patent | Assay Description Competitive binding assays were performed by incubating rhER alpha (α) and beta 1 (β1) receptors with 10 nM [3H]estradiol (the radio ligand... | US Patent US9688816 (2017) BindingDB Entry DOI: 10.7270/Q2WD3XR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen receptor (Rattus norvegicus (Rat)) | BDBM25807 (4,4 -Dihydroxybenzophenone | 4-[(4-hydroxyphenyl)c...) | PDB MMDB Reactome pathway KEGG B.MOAD GoogleScholar AffyNet | Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.45E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Basel Curated by ChEMBL | Assay Description Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) | J Med Chem 48: 5666-74 (2005) Article DOI: 10.1021/jm050403f BindingDB Entry DOI: 10.7270/Q2TM7CBZ | |||||||||||
More data for this Ligand-Target Pair |