null
SMILES: Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1nccs1
InChI Key: InChIKey=PGAPJRVJNZPHAS-ABAIWWIYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM258113 (US9493448, 15 | US9845313, Example 15) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 28 | n/a | n/a | n/a | n/a | 7.3 | 37 |
DAIICHI SANKYO COMPANY, LIMITED US Patent | Assay Description Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o... | US Patent US9493448 (2016) BindingDB Entry DOI: 10.7270/Q29022QD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM258113 (US9493448, 15 | US9845313, Example 15) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
DAIICHI SANKYO COMPANY, LIMITED US Patent | Assay Description Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The... | US Patent US9845313 (2017) BindingDB Entry DOI: 10.7270/Q25141H5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1 subunit alpha/subunit beta-1/subunit beta-2 (Homo sapiens (Human)) | BDBM258113 (US9493448, 15 | US9845313, Example 15) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of human NaV1.1/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology method | J Med Chem 63: 10204-10220 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1,3-beta-glucan synthase component GSC2 (Saccharomyces cerevisiae) | BDBM258113 (US9493448, 15 | US9845313, Example 15) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of human ERG by Ionworks high-throughput electrophysiology method | J Med Chem 63: 10204-10220 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel subunit beta-2 (Homo sapiens) | BDBM258113 (US9493448, 15 | US9845313, Example 15) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology method | J Med Chem 63: 10204-10220 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel subunit beta-2 (Mus musculus) | BDBM258113 (US9493448, 15 | US9845313, Example 15) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology method | J Med Chem 63: 10204-10220 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha/subunit beta-1/subunit beta-2 (Homo sapiens (Human)) | BDBM258113 (US9493448, 15 | US9845313, Example 15) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 6.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of human NaV1.5/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology method | J Med Chem 63: 10204-10220 (2020) | |||||||||||
More data for this Ligand-Target Pair |