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BDBM2584 (3R,4R)-3,4-bis(1H-indol-3-yl)pyrrolidine-2,5-dione::Bisindolylmaleimide deriv. 6::trans-3,4-Bis(3-indolyl)-2,5-pyrrolidinedione

SMILES: [H][C@]1(C(=O)NC(=O)[C@@]1([H])c1c[nH]c2ccccc12)c1c[nH]c2ccccc12

InChI Key: InChIKey=QBMMMCZNMCDPBJ-ROUUACIJSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 2584   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2584
PNG
((3R,4R)-3,4-bis(1H-indol-3-yl)pyrrolidine-2,5-dion...)
Show SMILES [H][C@]1(C(=O)NC(=O)[C@@]1([H])c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |r|
Show InChI InChI=1S/C20H15N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,17-18,21-22H,(H,23,24,25)/t17-,18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1016/j.bmc.2005.03.050
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair